Roger W. Giese

Professor of Chemistry and Biomedical Science; Director, Environmental Cancer Research Program
  • Department of Pharmaceutical Sciences
  • Faculty
  • School of Pharmacy

Résumé/CV:
Office: 140 TF, Room 202
Phone: 617-373-3227
Email: r.giese@northeastern.edu

Education:
Ph.D., MIT (Cambridge, MA)
BS, Hamline University

Certification: Diplomate, American Board of Clinical Chemistry

Specializations:
Analytical Chemistry
Mass spectrometry
Environmental Analysis

Research:
Clinical Diagnostics
DNA Adducts
Metabolomics

The research projects in Dr. Giese’s laboratory combine aspects of analytical chemistry, organic chemistry and biochemistry to make advances in the reagents and techniques available for trace organic analysis.  Emphasis is placed on the development of new methodology for high sensitivity and multi-analyte detection, applied especially to human samples. The principle detection technique being used for high sensitivity is mass spectrometry.  Examples of analytes of interest are DNA adducts (damage to genes by carcinogens) and metabolites/xenobiotics (metabolomics).

Recent Publications:

187. Wang, P., Fisher, D., Rao, A., Giese, R.W. (2012) Nontargeted Nucleotide Analysis Based on Benzoylhistamine Labeling-MALDI-TOF/TOF-MS: Discovery of Putative 6-Oxo-Thymine in DNA, Anal. Chem. 84, 3811-3819. PMCID:22409256.

188. Wang, P., Gao, J., Li, G., Shimelis, O., Giese, R. W. (2012) Nontargeted Analysis of DNA Adducts by Mass-Tag MS: Reaction of p-Benzoquinone with DNA, Chem. Res. Toxicol. 25, 2737-2743. PMCID:23113579.

189. Codero, J.F., Meeker, J. D., Sheahan, T., Padilla, I., Giese, R., Silevitch, M. B., Loch-Caruso, R. Kaeli, D., Alshawabkeh, A. Case Study: Puerto Rico Testsite for Exploring Contamination Threats. Geotechnical Special Publication (225 GSP): 3553-3562.

190. Tetz, L, M., Cheng, A. A., Korte, C. S., Giese, R. W., Wang, P., Harris, C., Meeker, J. D., Loch-Caruso, R. (2013) Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro, Toxicol. Appl. Pharmacol. 268, 47-54. PMCID:2336088.

191. Kautz, R., Wang, P., Giese, R.W. (2013) NMR at the Picomole Level of a DNA Adduct, Chem. Res. Toxicol., 26, 1424-1429. PMCID: 24028148.

192. Peluso, M., Munnia, A., Ceppi, M., Giese, R. W., Catelan, D., Rusconi, F., Godschalk, R. W. L., Biggeri, A. (2013) Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy. Mutagenesis, 28, 315-321. PMCID 3630521.

193. Peluso, M., Munnia, A., Tarocchi, M., Arciello, M., Balsano, C., Giese, R. W., Galli, A. (2014) Exocycilic DNA Adducts in a Murine Model of Non-alcoholic Steatohepatitis. J. Carcinog. Mutagen., S3:003. doi: 10.4172/2157-2518. S3-003.

194. Yao, Y., Wang, P., Giese, R. W. (2014) Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry, Rapid Commun. Mass Spectrom. 28, 653-661. doi: 10.1002/rcm.6816.