A New Metal-Organic Framework for Drug Delivery

2018
Research Category: Engineering and Technology
Presenter: Tenghua Gong
Additional Authors: Javier Fonseca, Sunho Choi
PI: Sunho Choi

The use of nanoparticles (NPs) in cancer and other medical applications seeks a set of relevant features: enhancement of the drug therapeutic action by increasing efficacy and/or decreasing toxicities; improvement of the pharmaceutical properties of drugs such as stability or circulating half-life; transcytosis of therapeutic molecules across tight epithelial and endothelial barriers; specific targeting of drugs in desired tissues, cells or organelles; co-delivering multiple active pharmaceutical ingredients (APIs) to improve therapy and avoid drug resistance; sustaining or stimulus triggered drug release; combination of diagnostic and therapeutic modalities (theranostic) to monitor the in vivo efficacy of a therapeutic agent; and new approaches for diagnosis, drug imaging and delivery by miniaturized medical devices. In-depth understanding of the biological behavior of NPs and their nano-bio interactions is necessary to create suitable NPs as drugs delivery systems and to overcome the challenges regarding the chemistry of those NPs. In this regard, a new MOF is under development to meet all the above-mentioned features. It is expected to show not only the basic characteristics of a nanocarrier (biocompatibility, biodegradability, nonappearance of toxicity, and improve pK and biodistribution when drug is released) but also valuable intrinsic characteristics (applicable size, high drug loading capacity, non-burst release, non-clearance from the bloodstream by MPS, easy surface modification, stimulus-response capacity, targeting potential and imaging potential), overcoming drawbacks of other nanocarriers and making us to consider a favorable project of drug delivery system.

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