More than six million people are living with knee implants in the United States, and the number of patients requiring knee replacements is expected to increase to more than 3.4 million per year by 2030. Yet the costs and benefits of total joint replacement procedures have not been fully evaluated. The need for effective strategies to improve quality of knee implants and the efficiency of procedures and operations is more apparent than ever. Using a model that simulates the adoption of patient-matched (PM) and traditionally manufactured off-the-shelf (OTS) implants, we present that a higher rate in PM adoption has positive long-term effects, not only on patient outcomes but also on the economics of the healthcare system. Results indicate that a higher rate of PM adoption ultimately saves hospitals and surgeons 11% on procedure time, decreases the recovery time by 30%, reduces the number of readmissions and revision surgeries by 2% and 4%, respectively, and lessen the costs for the stakeholders of the system by 18%.