• Proposal: 11/28/2017


  • Amount: Up to $600,000 per year
  • Duration: Up to 7 years


This Funding Opportunity Announcement (FOA) invites grant applications for the Outstanding Investigator Award (R35) in any area of cancer research.

The objective of the National Cancer Institute (NCI) Outstanding Investigator Award (OIA) is to provide long-term support to accomplished investigators with outstanding records of cancer research productivity who propose to conduct exceptional research. The OIA is intended to allow investigators the opportunity to take greater risks, be more adventurous in their lines of inquiry, or take the time to develop new techniques. The OIA would allow an Institution to submit applications nominating established Program Directors/Principal Investigators (PDs/PIs) for the NCI OIA.

It is expected that the OIA would provide extended funding stability and encourage investigators to embark on projects of unusual potential in cancer research. The research projects should break new ground or extend previous discoveries toward new directions or applications that may lead to a breakthrough that will advance biomedical, behavioral, or clinical cancer research.

Special features of the OIA include 7-year project periods; the expectation that the OIA PD/PI commit at least 6 person months effort to the OIA; the expectation of clear and substantial Institutional commitment to the PD/PI, for example, providing 20% of salary support; and that PD/PIs will be expected to renegotiate their time and effort on all other grant support, including NIH grants, in order to accommodate the OIA level of effort.  It is expected that the OIA will replace current NCI funding on individual research grants.

Eligibility & Submission Requirements

The NCI will only consider funding two additional research project grants to the Outstanding Investigator while the OIA is active.  This limit includes single PD/PI, multiple PD/PI and multi-project grants where the OIA Investigator is the PD/PI.