Deadlines
  • Proposal: 03/26/2020

Funding

  • Amount: $1.75m per year
  • Duration: 5 years

Scope

The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research.  Each CEGS award supports a multi-investigator, interdisciplinary team to develop transformative genomic approaches to address a biomedical problem.  A CEGS project will address a critical issue in genomic science, genomic medicine, or computational genomics, proposing a highly innovative solution that would be a major advance.  The research will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff.  A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, on a genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems or furthering the application of genomic knowledge, data, and methods towards clinical applications.   Each CEGS will nurture genomics at its institution by facilitating the interaction of investigators from several disciplines.  By training new and experienced investigators it will expand the pool of genomics scientists and engineers.

Clinical trials (optional):  CEGS applications may include activities that fit the clinical trials definition, such as testing whether new genomic assays or integration of genomic and clinical data improve a health outcome.  The purpose of this FOA is to support the development of transformative genomic approaches, and is not intended to fund applications whose primary focus is on recruitment and data production for a clinical trial.  The definition of clinical trials in NOT-OD-15-015 and https://grants.nih.gov/policy/clinical-trials/definition.htm is not intended to expand the scope of applications accepted by the CEGS program beyond studies that have a major genomic component and relate clearly to the aims of the program.  Any applications including clinical trials are required to address the information listed for clinical trials.  Applicants are strongly encouraged to discuss their research plans with NHGRI or NIMH program staff prior to submitting their applications.

Since the goal of the program is to stimulate rapid progress in genomics, it is expected that the results (e.g., publications, methods, data) will become available to the community throughout the duration of the award.  Methods, data, and software developed under CEGS support should be released quickly in a way that provides broad access.  See the Genomic Data Sharing policy at https://www.genome.gov/27562511/nhgri-implementation-of-nih-genomic-data-sharing-policy/ .

Preference will be given to the development of genomic methods for eukaryotes for which genome sequence and related data are already available.  Methods development or pilot studies using other systems (e.g., eukaryotes whose genomes have not been sequenced, or prokaryotes whose genomic sequence is known) will be considered with adequate justification; the direct applicability of approaches developed in such a project to the analysis of eukaryotic genomes must be evident.

Where appropriate, integration with other NHGRI or NIH genomic initiatives (e.g., ENCODE (ENCyclopedia Of DNA Elements) [http://www.genome.gov/10005107], 1000 Genomes [http://www.genome.gov/27528684], GTEx (Genotype-Tissue Expression)  [https://commonfund.nih.gov/GTEx], the Mammalian Gene Collection [http://mgc.nci.nih.gov], a Catalog of Published Genome-Wide Association Studies [http://www.genome.gov/26525384], ClinGen (Clinical Genome Resource) [https://www.genome.gov/27558993], or the PhenX Toolkit [http://www.genome.gov/27541903] will be considered advantageous.

Eligibility & Submission Requirements

Each CEGS application is required to include an education and outreach activity that leverages the strengths of the Center and its investigators to further educate interdisciplinary scientists, including students and faculty, who will bring creativity to biomedical problems through a genomic approach.

Contact Information

Scientific/Research Contact(s)

Adam Felsenfeld, Ph.D.
National Human Genome Research Institute (NHGRI)
Telephone: 301-480-2269
Email: adam_felsenfeld@nih.gov

Tara Dutka, Ph.D.
National Institute of Mental Health (NIMH)
Telephone: 301-451-3074
Email: Tara.dutka@nih.gov