• Proposal: 02/20/2020
  • Rolling


  • Amount: $500,000 per year
  • Duration: 5 years


ORIP uses the P40 mechanism to support Animal and Biological Material Resource Centers in a variety of areas of biomedical science. Animal and Biological Material Resource Centers create, collect, develop, characterize, preserve, and distribute special colonies of high-quality laboratory animals and animal-related models.  Special colonies of research animals are defined as animals that are valuable for biomedical research but are not generally available to investigators. Collecting, generating and distributing such animals render these resources more accessible to the research community and eliminate costly redundant efforts. Other types of Animal and Biological Material Resource Centers provide informatics tools, data, analytical expertise, biological materials, tools, or services that support research projects that will enhance and expand an animal model system. Of special interest are resources that emphasize use of broadly applicable, interdisciplinary validation tools to increase predictability of animal models, such as approaches to compare and determine relatedness and usefulness of a disease associated network/pathway/physiological process between an animal model and a human patient. Applications that heavily focus on building and maintaining genomic or phenotyping databases for individual animal species will not be considered for funding. Details concerning current Division of Comparative Medicine (DCM) Animal and Biological Material Resource Centers can be found at the following link:

All applicants are strongly encouraged to consult with DCM Program staff on the appropriateness of the intended resource plans for this program, competitiveness of a potential application, and whether the proposed application meets the goals and mission of the DCM/ORIP and is broad enough to serve needs of the wide biomedical community. Resource applications that are deemed limited to a narrow biomedical research community will not be considered for funding.

Examples of an inappropriate request are resources that exclusively maintain and distribute animals or biological materials for cancer, heart disease, neurological disorders, or other specific disease research areas. Projects involving threatened or endangered species will not be supported under this FOA.

Animal and Biological Material Resource Centers should have the following characteristics:

1)  There should be a demonstrated need for the resource in the wide biomedical research community. Evidence of the depth and breadth of impact on a scientific community must be provided. Examples could include up to 15 letters of support from institutions, individuals, groups, or consortia; website usage; a statement from a scientific society; and/or a published white paper. Applications exceeding number of letters limit will be administratively withdrawn without review;

2)  The Centers should serve the needs of investigators in a variety of research areas where work is sponsored by multiple NIH ICs.  If the user community is very narrow or limited to a research area supported by one NIH IC, support for the animal resource should be sought from the appropriate NIH IC. Furthermore, applications proposing creating resources that are related predominantly to the interest of one NIH IC and only peripherally to the interests of other ICs are not considered acceptable;

3) The Centers must be available and utilized by investigators on a local, regional, and national basis;

4) The Centers should ensure the quality and welfare of distributed animals and describe how their activities assist and promote optimization and enhancement of scientific rigor, transparency and experimental reproducibility of biomedical research;

5)  The Centers must have an Applied Research Component to generate new approaches or enhance existing ones that will improve the resources and services provided to the community.  Hypothesis driven R21- or R01-like research is not considered applied research. The Applied Research Component may comprise no more than 10 percent of the direct costs associated with the P40 grant;

6)  The Institution submitting the P40 application must be committed to the Center being proposed.  Evidence of such support must be provided. The application should include a letter(s) of support from the Institution;

7) A critical component of improving scientific reproducibility of the research is to develop approaches for unique identification of research resources in public databases, including publications. The Centers should register catalogs of their resources with current resource tagging and identification initiatives, such as FORCE 11 ( These Centers should also work with the investigators to encourage the use of a resource identification system in their publications and reports;

8) The Center should have a disaster plan to minimize total loss of resources in the event of a catastrophic disaster, such as loss of power, fire, flooding, or data breach;

9) The Center should develop an active program for monitoring and collecting information on the impact of their ongoing activities on biomedical research. Such information should also be included in their progress reports to the NIH.

Eligibility & Submission Requirements

Application budgets are not limited but need to reflect the actual needs of the proposed project.

Applicants requesting $500,000 or more in direct costs in any year (excluding consortium F&A) must contact a Scientific/ Research Contact for approval at least 6 weeks before submitting the application.

Contact Information

Scientific/Research Contact(s)

Oleg Mirochnitchenko, Ph.D.
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-435-0748