Faculty

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nu-seal

 Anne L. van de Ven, Ph.D.

Assistant Professor, Department of Physics
Director, Graduate Certificate in Nanomedicine
Associate Director, Nanomedicine Academy of Minority Serving Institutions
Associate Director, CaNCURE Cancer Nanomedicine Co-op Program
Director, Experimental Nanotherapeutics Laboratory

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Research Interests

Nanomedicine is ushering in an era of individualized therapy.  To realize this vision, we not only need advances in nanomaterials, but also new tools to study and optimize interactions at the bio-nano interface. My research combines high throughput nanoparticle synthesis with quantitative imaging & multi-scale modeling to optimize nanotherapeutics for cancer and antibiotic-resistant infections.  My areas of expertise include: intravital microscopy, magnetic resonance imaging, optical instrumentation, nanoparticle synthesis and characterization, drug delivery, and animal models of cancer.

Biography

Anne L. van de Ven, PhD, is an Assistant Professor of Physics and Director of the Graduate Certificate in Nanomedicine at Northeastern University.   She has 17 years experience in translational nanomedicine and experimental nanotherapeutics.  Dr. van de Ven has pioneered several educational initiatives to train students and increase the diversity of the nanomedicine workforce, including the Nanomedicine Academy of Minority Serving Institutions and the CaNCURE Cancer Nanomedicine Co-op Program.    She is the recipient of 3 awards from the National Cancer Institute, including the Physical Sciences in Oncology Pilot Project Award (×2) and the Young Investigator Trans-Network Award.  Dr. van de Ven received her Ph.D. in Bioengineering from Rice University under the supervision of Dr. Rebecca Richards-Kortum in 2008.  From 2009 to 2013, Dr. van de Ven received postdoctoral training in the laboratory of Dr. Mauro Ferrari, where she developed optical techniques for real-time monitoring individual nanoparticles in live mice.

Teaching

All courses are taught simultaneously to ~150 students/year at NEU, TU, UPRM, FIU, and MSU

NNMD 5270 – Introduction to Nanomedicine Science & Technology

NNMD 5370 – Nanomedicine Research Techniques

NNMD 5470 – Bio- and Nanomedical Commercialization: From Concept To Market

NNMD 5272 & 5274 – Nanomedicine Seminar Series

Publications
  1. Mitra R, Qiao J, Madhavan S, O’Neil GL, Ritchie BL, Kulkarni P, Sridhar S, van de Ven AL, Cherry EM, Ferris C, Hamilton JA, Ebong EE. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Translational Medicine Communications, 2018. 3:10. Article
  2. Gharagouzloo C, Timms L, Qiao J, Fang Z, Nneji J, Pandya A, Kulkarni P, van de Ven AL, Ferris C, Sridhar S. Neural circuits and brain function: New insights using quantitative vascular mapping of the rat. Neuroimage, 2017. 16C:24-33. Article
  3. Gharagouzloo C, Timms L, Qiao J, Fang Z, Nneji J, Pandya A, Kulkarni P, van de Ven AL, Ferris C, Sridhar S. Dataset on a 173 region awake resting state quantitative cerebral blood volume rat brain atlas and regional changes to cerebral blood volume under isoflurane anesthetization and CO2 challenge. Data in Brief, 17:393-396.  Article
  4. Belz J, Kumar R, Baldwin P, Castilla Ojo N, Leal AS, Royce DB, Di Zhang D, van de Ven AL, Liby K, Sridhar S. Sustained-release Talazoparib implants for localized treatment of BRCA1-deficient breast cancer. Theranostics. 2017. 7(17): 4340-4349.  Article
  5. van de Ven AL, Tangutoori S, Baldwin P, Qiao J, Gharagouzloo C, Seitzer N, Clohessy JG, Makrigiorgos GM, Cormack R, Pandolfi PP, Sridhar S. Nanoformulation of Olaparib amplifies PARP inhibition and sensitizes PTEN/TP53-deficient prostate cancer to radiation. Molecular Cancer Therapeutics, 2017.16(7):1279-1289.  Article
  6. Geilich B, Gelfat I, Sridhar S, van de Ven AL, Webster TJ. Superparamagnetic iron oxide-encapsulating polymersome nanocarriers for biofilm eradication. Biomaterials, 2017. 119:78-85. Article
  7. Barlow J*, Gozzi K*, Kelley CP, Geilich B, Webster T, Chai Y, Sridhar S, van de Ven AL. High throughput microencapsulation of Bacillus subtilis in semi-permeable biodegradable polymersomes for selenium remediation. Applied Microbiology and Biotechnology, 2016.  Article * Equal contributions.
  8. Paro AD, Shanmugam I, van de Ven AL. Nanoparticle-mediated x-ray radiation enhancement for cancer therapy. Cancer Nanotechnology: Methods and Protocols (Reema Zeineldin, Ed) 2016. In Press.
  9. Evangelopoulos M, Parodi A, Martinez JO, Yazdi IK, Cevenini A, van de Ven AL, Quattrocchi N, Boada C, Taghipour N, Corbo C, Brown BS, Scaria S, Liu X, Ferrari M, Tasciotti E. Cell source determines the immunological impact of biomimetic nanoparticles. Biomaterials, 2016. 82:168-177.  Article
  10. van de Ven AL, Shann MH, Sridhar S. Outcomes of an interdisciplinary, dual-mentor doctoral training program in Nanomedicine. American Society for Engineering Education. In, Northeast Section on American Society for Engineering Education Conference, Boston, MA April 30-May 2, 2015.
  11. van de Ven AL, Shann MH, Sridhar S. Essential components of a successful doctoral program in Nanomedicine. International Journal of Nanomedicine, 2015; 10:23-30.  Article
  12. Geilich B, van de Ven AL, Singleton GL, Sepulveda LJ, Sridhar S, Webster TJ. Silver nanoparticle-embedded polymersome nanocarriers for the treatment of antibiotic-resistant infections. Nanoscale, 2015; 7(8):3511-3519.  Article
  13. van de Ven AL, Geilich B, Gharagouzloo C, Barlow J, Webster TJ, Sridhar S. Polymersomes for image-guided therapy. Northeast Bioengineering Conference (NEBEC), 2014 40th Annual.  Article
  14. Yokoi K, Tanei T, Godin B, van de Ven AL, Hanibuchi M, Matsunoki A, Alexander J, Fidler I, Ferrari M.  Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments. Cancer Letters, 2014; 345(1):48-55.  Article
  15. Tang L, van de Ven AL, Guo D, Andasari V, Cristini V, Li KC, Zhou X. Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. PLOS One, 2014; 9(1):e83962.  Article
  16. Kirui DK, Mai J, Palange AL, van de Ven AL, Liu X, Shen H, Ferrari M. Transient mild hyperthermia induces E-selectin mediated localization of mesoporous silicon vectors in solid tumors. PLOS One, 2014; 9(2):e86489. Article
  17. van de Ven AL, Kim P, Ferrari M, Yun SH. Real-time intravital microscopy of individual nanoparticle dynamics in liver and tumors of live mice. Nature Protocol Exchange, 2013; Article
  18. Parodi A*, Quattrocchi N*, van de Ven AL, Chiappini C, Martinez JO, Brown BS, Evangelopoulos M, Khaled SZ, Yazdi IK, Enzo MV, Ferrari M, Tasciotti E. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nature Nanotechnology, 2013; DOI: 8: 61-68.  Article  * Equal contributions.
  19. van de Ven AL, Abdollahi B, Martinez C, Burey LA, Landis MD, Chang JC, Ferrari M, Frieboes, HB.  Modeling of nanotherapeutics delivery based on tumor perfusion. New Journal of Physics, 2013; 15: 055004.  Article
  20. Celia C, Ferrati S, Bansal S, van de Ven AL, Ruozi B, Zabre E, Hosali S, Paolino D, Sarpietro MD, Fine D, Fresta M, Ferrari M, Grattoni A. Sustained Zero-Order Release of Intact Ultra-Stable Drug-Loaded Liposomes from an Implantable Nanochannel Delivery System. Advanced Healthcare Materials. 2014 Feb;3(2):230-8. Article
  21. Guo D, van de Ven AL, Zhou X. Red blood cell tracking using optical flow methods.   IEEE Transactions on Information Technology in Biomedicine, 2014 May;18(3):991-8. Article
  22. Fine D, Grattoni A, Goodall R, Bansal SS, Chiappini C, Hosali S, van de Ven AL, Srinivasan S, Liu X, Godin B, Brousseau L, Yazdi IK, Fernandez-Moure J, Tasciotti E, Wu H-J, Hu Y, Klemm S, and Ferrari M. Silicon micro- and nanofabrication for medicine. Advanced Healthcare Materials, 2013, 2(5): 632-666.  Article
  23. van de Ven AL, Kim P, Haley O, Fakhoury J, Adriani G, Schmulen J, Moloney P, Liu X, Hussain F, Ferrari M, Yun SH, Decuzzi P. Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution. Journal of Controlled Release 2012; 158(1): 148-155.  Article
  24. van de Ven AL, Wu M, Lowengrub J, McDougall SR, Chaplain M, Cristini V, Ferrari M, Frieboes HB. Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors.   American Institute of Physics (AIP) Advances 2012; 2(1): 011208.  Article
  25. van de Ven AL, Mack AC, Dunner K, Ferrari M. Serda RE. Preparation, characterization, and cellular association of silicon LEVs. In, Methods in Enzymology: Nanomedicine. (Duzgunes N, Ed) 2012; 508:1-16.   Article
  26. Sakamoto JH, Godin B, Hu Y, Blanco E, van de Ven AL, Vellaichamy A, Murphy M, LaFrancesca S, et al. “Nanotechnology towards advancing personalized medicine.” Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery, and Therapy. (IS Viziranakis, Editor) 2013, Pan Stanford Publishing Pte Ltd. ISBN: 9789814411196‡
  27. Serda RE, Blanco E, Mack A, Stafford SJ, Amra S, Li Q, van de Ven AL, Tanaka T, Torchilin VP, Wiktorowicz JE, Ferrari M. Proteomic analysis of serum opsonins impacting biodistribution and cellular association of porous silicon microparticles. Molecular Imaging 2011; 10(1): 43-55.   Article
  28. Serda R, Mack A*, van de Ven AL*, Ferrati S, Dunner K, Godin B, Chiappini C, Landry M, Brousseau L, Liu X, Bean AJ, and Ferrari M. Logic-embedded vectors for intracellular partitioning and exocytosis of nanoparticles. Small 2010 Dec; 6(23): 2691-700. Article  * Equal contributions.
  29. Sakamoto JH, van de Ven AL, Godin B, Blanco E, Serda R, Grattoni A, Ziemys A, Hu T, Ranganathan SI, DeRosa E, Martinez JO, Smid CA, Buchanan RM, Lee S, Srinivasan S, Meyn A, Tascotti E, Liu X, Decuzzi P, Ferrari M. Enabling individualized therapy through nanotechnology. Pharmacological Research 2010; 62 (2): 57-89.  Article
  30. Goshn B*, van de Ven AL*, Sokolov K, Gillenwater A, Richards-Kortum R, Roy K. Efficient mucosal delivery of optical contrast agents using imidazole-modified chitosan. Journal of Biomedical Optics 2010; 15(1):015003.   Article  * Equal contributions.
  31. van de Ven AL, Adler-Storthz K, Richards-Kortum R. Delivery of optical contrast agents using Triton-X100, Part 1: Reversible permeabilization of live cells for intracellular labeling. Journal of Biomedical Optics 2009; 14(2): 021012.    Article
  32. van de Ven AL, Adler-Storthz K, Richards-Kortum R. Delivery of optical contrast agents using Triton-X100, Part 2: Enhanced mucosal permeation of topical contrast agents for the detection of cancer biomarkers.  Journal of Biomedical Optics 2009; 14(2): 021013.   Article

‡ Republished in: Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk (R Bawa, G Audette, and B Reese) 2016, Pan Stanford Publishing PTE Ltd, Singapore. ISBN: 978-981-4669-22-1

 

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