Targeted Nanocarriers

Targeted Nanocarriers

Student: Tatyana Chernenko
Department: Chemistry
Advisor: Max Diem

Abstract

Non-invasive imaging techniques, such as Raman micro-spectral biochemical imaging techniques have been gaining recognition in the field of pharmaceutical research. It has the potential to provide not only the topographical sample information, but also morphological, biochemical data of a sample.
We have applied this technique to acquire information about internalization kinetics and intracellular dynamics of EGFR-targeted and non-targeted biodegradable drug-delivery carriers with and without a therapeutic payload. Employing diverse unsupervised multivariate statistical methods of data analysis yield excipient-specific biochemical behavioral patterns within a cell.