Targeted eNOS Gene Delivery with Lipopolyplexes for the Treatment of Coronary Restenosis

Student: Luis Brito
Department: Pharmaceutical Sciences
Advisor: Mansoor Amiji

Abstract

The main thrust of this research is to develop gene therapy strategy using safe and effective non-viral vectors for local production of endothelial nitric oxide synthase (eNOS) on arterial wall. Local eNOS production has shown to regulate many biological functions, including regeneration of arterial endothelium after coronary angioplasty and prevention of restenosis.