The skin is a critical barrier to the environment that requires robust healing mechanisms to prevent infections. Repair of the skin is complex, requiring the coordination of numerous cell types in a time sensitive cascade.
The Crane Lab studies the fundamental mechanisms underlying defects in skin tissue regeneration, repair and remodeling. We focus on the regulation of cellular repair in chronological and sun damage-induced aging as well as diabetes. Our main areas of focus surround the impact of metabolic signaling in skin disorders.
Understanding the mechanisms of the anti-aging properties of exercise. Recently, we found that IL-15 was a signaling molecule released during exercise which improves aging skin structure and boosts cellular mitochondria. Ongoing work is testing the effects of IL-15 therapy to improve skin repair and protect against damage. Energetic signaling and metabolism in epidermal stem cell maintenance. Most reserach in metabolism has focused on highly energetic tissues such as liver, muscle brain or cancer cells. However, we know very little about how energy signaling impacts the maintenance and repair of the skin. We are studying this signaling in several areas of skin biology: What is the role of mitochondria and metabolic signaling in the skin? Does an energetic deficit or impaired energy sensing cause skin pathologies?
Mediators of scar tissue formation and fibroblast-epithelial cross-talk.
Developing new imaging methods to better characterize skin regeneration.