Core Facility

Please contact Guoxin Rong with regard to the general use policy and new user trainings

Announcements

ATTENTION: The ICILS Core is open to NU researchers who have fulfilled the requirements outlined in this COVID-19 Laboratory Reopening Plan.
Note: We are now offering 90% off rate for nightly (6PM-9AM) and weekend usage to encourage schedule staggering during COVID-19 Pandemic

Publications

Please acknowledge ICILS in your publication! We suggest the following text in the acknowledgements section of your paper: “We thank the Institute for Chemical Imaging of Living Systems at Northeastern University for consultation and imaging support”

2020

3D Visualization of Macromolecule Synthesis. eLife [Monaghan/Shefelbine Lab]

Self-Assembled DNA–PEG Bottlebrushes Enhance Antisense Activity and Pharmacokinetics of Oligonucleotides. ACS Appl. Mater. Interfaces. [Zhang Lab]

A DNA-Based Optical Nanosensor for in vivo Imaging of Acetylcholine in the Peripheral Nervous System. Biorxiv. [Clark/Monaghan Lab]

Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies. Appl Environ Microbiol. [Li Lab]

Site‐Specific Bioconjugation and Convergent Click Chemistry Enhances Antibody–Chromophore Conjugate Binding Efficiency. Photochem Photobiol. [Spring/Zhou Lab]

High-Power Light-Emitting Diode Array Design and Assembly for Practical Photodynamic Therapy Research. J. of Biomedical Optics. [Spring Lab]

Optical Nanosensors for in vivo Physiological Chloride Detection for Monitoring Cystic Fibrosis Treatment. Anal. Methods. [Clark Lab]

Real-Time Particle-by-Particle Detection of Erythrocyte-Camouflaged Microsensor with Extended Circulation Time in the Bloodstream. PNAS. [Clark/Niedre Lab]

Equipment

Zeiss LSM 800

  • Laser line: 405, 488, 561, 640 nm
  • Objective: , 10×, 20×, 40×, 63×
  • Fixed cell/tissue imaging,
  • Image Tiling
  • NU user: 30$/hr; Academia: $50/hr; Industry: 70$/hr

Zeiss LSM 880

Zeiss LSM 880 NLO

  • Laser line: 405, 458, 488, 514, 561, 594, 640 nm
  • NIR Laser: tunable line (680-1300 nm); fixed line -1045 nm
  • Objective: 10×, 20×, 20×, 40×, 20×-CLARITY
  • Multi-photon imaging
  • Superresolution (Airyscan)
  • Spectral Unmixing
  • NU user: 50$/hr; Academia: $70/hr; Industry: 90$/hr

Zeiss Lightsheet Z1

  • Laser line: 405, 488, 561, 638 nm
  • Objective: 5×, 10×-water, 20×-CLARITY
  • CO2/temperature control,
  • Large scale 3D tissue imaging
  • arivis Vision4D software
  • NU user: 50$/hr; Academia: $70/hr; Industry: 90$/hr

Zeiss AxioZoom V16

  • Continuous zoom with high NA
  • Large filed of view
  • Apotome.2 Structured Illumination Module
  • In vivo and model organism Imaging
  • NU user: 20$/hr; Academia: $30/hr; Industry: 40$/hr

Bruker Biospec 3T MRI

  • Automated animal positioning
  • Multimodal rat/mouse cradle
  • Two body volume coils for rat/mouse
  • SAII 1030 monitoring/gating module
  • Localized MR Spectroscopy
  • NU user: 20+$/hr; Academia: $150/hr; Industry: 200$/hr