Raymond G. Booth, professor of pharmaceutical sciences and chemistry
Booth has been on a 25-year mission to develop a drug that does a better job treating schizophrenia and other psychiatric disorders, including addiction. And now he’s close to seeing his vision become reality.
Medications to manage schizophrenia have existed since the 1950s. But their side effects—sedation, neurological disorders, and extreme weight gain—mean patients often don’t stick to treatment plans. And current drugs aren’t nuanced enough to correct the imbalanced brain neurotransmission that underlies psychiatric disorders.
But Booth’s drug, Bromopatin, acts in a novel way to rebalance neurotransmission of the brain neurochemical serotonin. Bromopatin turns down activity of some serotonin receptors while turning up activity for others. Preclinical testing suggests no serious side effects.
Booth is working with pharmaceutical development partners toward clinical trials. If all goes well, Bromopatin could be available in a few years, bringing hope to the millions of people coping with schizophrenia and other psychiatric disorders.