Co-Silencing of PKM-2 and MDR-1 Sensitizes Multidrug Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer

Purpose: The aim of our study was to evaluate the effectiveness of combination therapy with siMDR-1 and siPKM-2 in SKOV-3WT and SKOV-3TR human ovarian adenocarcinoma cell lines and xenograft models. Using hyaluronic acid (HA)-based self-assembling nanoparticles targeted for the epidermal growth factor receptor (EGFR) on the surface. We aimed to investigate whether co-silencing of PKM-2 … See More

In Vitro Metabolite Identification and Characterization of MAK-1616 Using LC-MS/MS–Offline Microcoil NMR

In drug discovery, we are often confronted with the case where a compound shows very good receptor affinity and selectivity, but is plagued by poor metabolic stability which affects its desired pharmacokinetic and pharmacodynamic properties, thus diminishing its potential as a prospective clinical candidate. In depth knowledge of metabolism can help identify soft spots on … See More

The Impact of Medical Jargon on Perceptions of Disease: A Comparison of Medical Students and Lay People

According to statistics reported by the American Heart Association and the Centers for Disease Control, 735,000 Americans have a heart attack every year and 1 in every 4 deaths are from heart disease. How does the use of medical jargon (“medicalese”) versus lay terminology affect people’s perceptions of the seriousness of a person’s condition and its disease-like qualities? How does it affect people’s self-reported intent to adhere … See More

Can Simulation Enhance Self-Reported Confidence in Physical Therapist Students

Abstract: Background and Purpose: Simulation education has been proven to be beneficial in many health professions, including physical therapy, to increase patient safety, teamwork, and interprofessional practice. Research into the benefits of simulation in early years of a physical therapy curriculum is not well known. The purpose of this study was to gather outcome data and … See More

Non-Linear Exercise Training in Patients with Cystic Fibrosis

Introduction: The purpose of this literature review was to collect and interpret the literature available regarding non-linear exercise training in healthy populations, linear and non-linear exercise programs in people with lung disease, especially cystic fibrosis, and specific pathological processes in cystic fibrosis and their responses to exercise. Methods: Scientific databases such as PubMed and EBSCOhost … See More

Are Health and Wellness Needs Being Addressed for College Students?

Objective: The American College Health Association recommends including nutrition, sleep, stress and mental health, eating disorders, alcohol and tobacco usage, preventative care, sexual health, financial health, and exercise topics for a comprehensive health and wellness program for college students. The objective of this systematic review is to identify evidence to support positive changes for programs … See More

Exploring the Culture of Concussion Safety in Major League Lacrosse: A Pilot Study

Purpose: Lacrosse is one of the fastest growing sports and concussion is among the most common athletic injuries. The purpose of this study was to explore concussion knowledge and culture of concussion safety among Major League Lacrosse (MLL) players.  Methods: Sixty-three male athletes, mean age 27 ± 3.45 years, participated.  Subjects were all MLL players … See More

A Survey of Physical Therapists’ Utilization of The Pilates Method in Rehabilitation

Background: The Pilates method was developed to address the mental and physical well-being of individuals with postural deformities, polio and other orthopedic impairments.  Current literature, although limited, demonstrates that Pilates may be a beneficial rehabilitation tool.  The purpose of our study is to investigate Pilates utilization by physical therapists.   Methods: A survey was created … See More

The Effect of Radiological Imaging on Structure Identification in Lower Extremity Cadaver Cross-sections

Gross anatomy cadaver lab is a foundational course in physical therapy curriculum. Incorporating radiological imaging into gross anatomy lab has been shown to improve the understanding of anatomy. The purpose of this study was to determine if exposure to radiological imaging during cadaver lab increased students' comprehension of a difficult anatomical concept, cross-sectional anatomy. Students … See More