Evaluation of Antibiotic Management in the Reduction of COPD Exacerbations

Introduction: Chronic Obstructive Pulmonary Disease (COPD) exacerbations increase morbidity and mortality. Controversy remains over the use of antibiotics during exacerbations. This study explores the clinical significance of antibiotics in COPD, and their impact on patient care. Methods: This IRB approved study retrospectively collected data from hospitalized patients admitted with a primary or secondary diagnosis of … See More

Thinking Outside the Topical Steroid Box: A Systematic Review of Topical Steroid Withdrawal (TSW) in Children Diagnosed with Eczema

BACKGROUND: For more than 60 years, topical steroids (TS) have been the mainstay of treatment for atopic dermatitis or eczema. However, the adverse effects of TS in medical literature and practice have been downplayed or overlooked.  One of these adverse effects is Topical Steroid Withdrawal (TSW). A National Eczema Association study prompted by social media reports concluded that … See More

Current Practices and Perceptions of Critical Care Pharmacists on the Use of Vasopressin in Patients with Septic Shock: A Prospective Survey

Introduction Controversy exists regarding the role of IV vasopressin as an intervention to help increase blood pressure in patients with septic shock.  In November 2014, the acquisition price of vasopressin increased 30-fold, causing ICU clinicians to re-evaluate the role of vasopressin in their patients with septic shock.  The purpose of this study was to determine … See More

Targeted Delivery of Polymer Pro-Drug Conjugate to Treat Drug Resistance in Cancer

Rationale: Cancer cells over-express many tumor associated receptors. We propose that use of pretargeting approach for active targeting of polymer-pro-drug conjugates (PPDCs) to drug resistant cancer cells utilizing bispecific antibody complexes could lead to better therapeutic outcome.   Methods: Bispecific antibody complexes consisting of either anti-DTPA Fab covalently-linked to anti-HER2 affibody or biotinylated intact anti-DTPA … See More

Trunk Kinematics and Neuromuscular Control in Athletes With and Without Patellofemoral Pain During a Lateral Step-Down Test

Background: Patellofemoral pain syndrome (PFPS) is a clinically challenging condition commonly occurring in athletes. PFPS has been associated with hip muscle weakness and altered neuromuscular control and lower extremity kinematics. However, the relationship between PFPS and trunk control is unclear. Purpose: The purpose of our study was to examine the relationship between trunk kinematics, neuromuscular … See More

The Influence of Exploring Academic Careers Elective Course on Former Students’ Post-Graduate Experiences

As pharmacy schools emerge across the country, pharmacy graduates have opportunities to enter a myriad of careers where they educate individuals, including patients, students and other health-care professionals. Many students are unaware of academic careers and the roles and responsibilities that faculty play in the class, department, and college. Moreover, many graduates are not well … See More

Gadolinium Nanoparticles for MR-Guided Radiation Therapy

Purpose: While more than 50% of all cancer patients receive radiation therapy during clinical care, the delivery of a curative radiation dose is constrained by the proximity of healthy tissues. To confront this clinical issue, we proposed to use AGuIX, a dual modality nanoparticle with radiosensitization and MRI contrast properties. MRI is increasingly used in radiation … See More

Improving Peripheral Nerve Regeneration via Optogenetic Stimulation of Glial Cells

The peripheral nervous system is considered capable of regenerating after injuries in optimal environments. However, this regeneration is limited in complex injuries and diminishes with time, leaving thousands of patients with uncompleted recovery and disabilities. Biophysical methods proposed to stimulate further regeneration, e.g. electrical stimulation and ultrasound, lack independent control over individual cell populations in … See More

Community Pharmacist Involvement in Prescription Drug Monitoring Programs

Electronic prescription drug monitoring programs were created in effort to reduce opioid abuse. However, the full impact of these programs has not been seen due to non-mandatory enrollment for all healthcare providers. Community pharmacists can help improve quality of care and play a more active role in the patient-care process through the use of prescription … See More