An observational case series study of patients undergoing ibogaine-assisted treatment for opiate drug dependence was completed in August, 2012. æA total of thirty subjects were drawn from patients treated independently for opiate drug dependence at one of two clinics in Mexico. æThese subjects were enrolled and followed for one year post-treatment. Baseline interviews were conducted either in person or video Skype prior to treatment and all follow up interviews were done by phone each month following treatment for a total of thirteen interviews. æThe primary outcome measure was the Addiction Severity Index Lite (ASI-Lite) taken at baseline and compared with the subsequent follow up interviews. æSecondary measures include the Subjective Opiate Withdrawal Scale (SOWS), the States of Consciousness Questionnaire (SOCQ), the Beck Depression Inventory, and the Trait Emotional Intelligence Questionnaire, Short From (TEIQue-SF). æSubjects were also required to submit to drug testing, twice using hair samples, or three times for urine. æResults indicate there were no adverse events directly related to ibogaine treatment. æLess than one third of the subjects relapsed within the first months, 60% within first two months, and 80% within six months. æFour subjects remained abstinent for over a year following a single treatment. æOf the subjects that relapsed after treatment, their usage patterns remained substantially lower and followed with interspersed periods of abstinence. æThe study provided key insights into how successes are achieved amongst the subjects who remained abstinent, and provide evidence for more future study.