Post-operative Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) infections after the surgical implantation of a prosthetic device can lead to major complications. Thus, reducing bacterial adhesion to the surface of these implanted materials will help to reduce the incidence of infection. Lubricin (LUB) is an amphiphilic glycoprotein found in the synovial fluid that plays a major role in its lubricating and anti-cell-adhesive properties. LUB has a mucin-like center domain and vitronectin-like globular tail domains. This study investigated lubricinÍs ability to prevent bacterial attachment and proliferation on polymer surfaces. The findings from this study indicated that lubricin is able to reduce the attachment and growth of Staphylococcus aureus on tissue cultured polystyrene over the course of 24 hours by approximately 13.9%. This study also indicated that vitronectin, a homologous protein lubricin, is able to reduce bacterial growth and adhesion in tissue culture polystyrene by approximately 11%. This study also indicated that although the reduction of bacterial proliferation on mucin coated surfaces may not be as drastic as seen with lubricin, mucin coatings can significantly reduce the amount of biofilm that is able to adhere to a to the surface of tissue culture polystyrene. Overall reducing the initial attachment and growth of bacteria on a surface as well as suppressing initial biofilm formation can have a drastic effect on medical implants. Overall, these initial reductions lead to improved patient outcomes by stopping the bacteria before they are able to form a strong foot hold that will lead to an infection..