Assessment of bone density distribution and fracture risk using Positron Emission Tomography and the Finite Element Method: A Preliminary Study

Abstract

Positron Emission Tomography (PET) can be used for whole body scanning to detect metastases in either soft tissue or bone. Normal bone is subject to continuous remodeling through the coordinated activity of osteoclasts and osteoblasts. The fluoride (18F) tracer appears specific for osteoblasts, and thus bone formation. Conversely, high fluorodeoxyglucose (FDG) tracer uptake is observed where metabolic activity is high. It appears specific for osteoclasts, and thus bone resorption. We hypothesize that knowledge of local remodeling activity can yield the local density and that functions developed relating standardized uptake values (SUV