Sponsor: NIH - National Institute of Health
Sponsor Program Solicitation:
Funding Amount: Up to $1.5M per year
Duration: 5 years`
Status of this Limited Submission Opportunity
NU Pre-Proposal Deadline: 07/17/2015
Sponsor Deadline: 09/17/2015
Eligibility and Nomination Requirements
Only one proposal may be submitted by an eligible organization.
If interested in submitting, please contact Karen Drew (-4824) and by NO LATER THAN July 17, 2015, submit a White Paper according to the NU Procedure for Programs with Limited Submissions.
NIMHD Transdisciplinary Collaborative Centers (TCCs) for health disparities research comprise regional coalitions of research institutions and consortium partners focused on priority research areas in minority health and health disparities. The TCC program’s overarching goal is to develop and disseminate effective interventions that can be implemented in real-world settings. The program is not intended to support activities targeting a single neighborhood, municipal jurisdiction, or service provider site in isolation; rather, TCC projects are expected to be regional in scope, population based, and placed in the context of regional or national efforts to promote health equity.
Benefits from medical advances are not always distributed equitably, often because structural or systemic factors limit the effectiveness of new diagnostic or therapeutic approaches in disadvantaged populations. Precision medicine (http://www.nih.gov/precisionmedicine/) is an emerging approach for disease prevention, early detection and treatment that takes into account individual variability in genes, environment, and lifestyle. While it holds great promise for improving patient care, its potential for reducing health disparities hinges on (1) better understanding of the dynamic interplay between biological, behavioral, social and environmental health risk and protective factors experienced across the life course, and (2) greater inclusion of health disparity populations in research aimed at developing precision medicine interventions. An integrative, inclusive approach toward the development of precision medicine is vital for improving health risk assessment and using that information to predict optimal interventions that not only benefit individual patients but also extend health benefits equitably within and across patient populations.
TCCs supported through this initiative are expected to focus on at least one priority research area outlined below, each combining expertise in precision medicine, population health disparities, and the science of translation, implementation and dissemination to address one or more documented health disparities. The proposed work must focus on one or more health disparities populations, which include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations and rural populations.
Each center will support 2-3 multidisciplinary research projects examining complementary aspects of precision medicine, focusing on interactions between biological, behavioral, and contextual predictors of disease vulnerability, resilience, and response to therapies in patients from disadvantaged communities. For the purposes of this FOA, biological predictors can include but are not limited to genomic, epigenomic, proteomic, metabolomic, and microbiomic variations as well as standard clinical laboratory markers (e.g., blood lipids, inflammatory markers, HbA1c, vitamin D3, etc.), behavioral measures, and other quantitative or qualitative indicators of health status in the study population(s).
Applications are expected to demonstrate substantive community input into the identification of research questions to be addressed by the proposed TCC and relevant contextual predictors to be examined in conjunction with biological predictors. For the purpose of this FOA, ‘community’ refers to a group or population that may be defined by geography, race, ethnicity, culture, gender, disease or other health condition, or a common health-related interest or concern.
In addition to the required collaborative research projects, each TCC award will support an Administrative Core, a Consortium Core, and an Implementation Core. The Administrative Core will manage and coordinate implementation of proposed TCC activities, including project evaluation; ensure that component plans are implemented according to proposed timelines; coordinate TCC Steering Committee activities and submission of annual progress reports; monitor progress on research sub-projects and ensure that TCC-supported research, including pilot projects, is carried out in compliance with applicable federal regulations and policies.
Applications may propose additional (optional) technical cores to help support the proposed research projects. Examples include but are not limited to clinical research cores, bioinformatics cores, genomics cores, biostatistics/study design cores, bioethics and regulatory knowledge cores, biospecimen repositories, data warehouses, etc. NOTE: TCC awards will not support cores that duplicate institutional resources or cores supported by other federal funding if such cores/resources are already available for use by TCC participants.