Chemistry

  • Direct Alloy Synthesis from Heteropolymetallic Precursors

    The inventions describe novel methods for producing metal composites and alloys of high surface area and catalytic efficiency.

    Inventors: Geoffrey Davies, Hui-Li Shao
    US Patent No.: 5,061,313

  • Method of Reconstituting Cellular Spectra from Spectral Mapping Data

    The present invention relates to methods for the automated screening of exfoliated cells to detect the presence of abnormalities (e.g. cancer).

    Inventors: Max Diem, Milos Miljkovic, Melissa Romeo, Benjamin Bird, Jennifer Schubert
    PCT Application filed in April 2009

  • Comprehensive Characterization of Complex Proteins at Trace Levels

    The invention allows the characterization of overlapping protein fragments. It covers the process by which a nested set of fragments can be put together to describe the complete protein sequence with detailed knowledge of the occurrence of post-translational modifications.

    Inventors: William Hancock, Barry Karger, Shiaw-Lin Wu
    Patent Application No.: 11/661,525

  • Novel Steroidal Anti-estrogens and Antiandrogens and Uses Thereof

    Novel estradiol derivatives show promise for hormone replacement therapy, treatment and prevention of breast cancer, and treatment of prostate cancer.

    Inventor: Robert Hanson
    US Patent No.: 7,041,839

  • Precision-Guided Nanoparticle Systems for Drug Delivery

    The invention is a novel approach for preparing targeted delivery systems.

    Inventors: Robert Hanson, Mansoor Amiji, Volkmar Weissig
    Patent Application No.: PCT/US2008/001766

  • Biaryl Amino Acids as Modulators of Nuclear Receptor Coregulatory Protein Binding

    The invention describes novel synthesized compounds that modulate hormone receptors. Use of these compounds allows for a more specific and targeted approach to the modulation process (i.e. "personalized medicine").

    Inventor: Robert Hanson
    Patent Application No.: PCT/US09/37986

  • Steroidal Anti-Hormone Hybrids as Novel Therapeutic Agents

    This invention provides an example of a hybrid compound that can be used to modulate disease processes. The invention describes the development of new chemotherapeutic agents by coupling two biologically active compounds in order to make a single hybrid agent.

    Inventor: Robert Hanson
    Provisional Patent Application No.: 61/146,934

  • Parallel Sample Injection for Multichannel Microfluidic Devices

    A universal interface and sample load injection device (integrated or separated from microchip) for the parallel introduction and simultaneous or sequential injection of liquid samples into channels of a microfluidic device.

    Inventors: Barry Karger, Frantisek Foret, Tomas Rejtar, Bailin Zhang
    US Patent No.: 6,939,452

  • Microchip Integrated Open-Channel Electroosmotic Pumping System

    Electroosmotic pumping and valving systems used to control fluid flow in microfluidic chips.

    Inventors: Barry Karger, Iulia Lazar
    Patent Application No.: 10/478,612

  • Matched Filtration with Experimental Noise Determination for Denoising, Peak Picking and Quantitation in LC-MS. (MEND)

    The technology (MEND) is a method, algorithm and software for analyzing a multi-dimensional data set that increase the reliability of peak detection and identification in the presence of chemical and/or random noise.

    Inventors:Victor Andreev, Tomas Rejtar, Barry Karger
    Patent Application Number: 10/510,992

  • Method for Efficient Transport of Small Liquid Volumes in Microfluidic Devices

    The technology enables the transfer of small concentrated samples from an automated sample handler through such lengths of capillary tubing into a Nuclear Magnetic Resonance (NMR) probe and other devices, with less than 5% loss or carryover.

    Inventors: Barry Karger, Roger Kautz
    Patent Application No.: 10/582,599

  • Subatomospheric, Variable Pressure Sample Delivery Chamber for Electrospray Ionization/Mass Spectrometry and Other Applications

    The invention is a method for the introduction of a sample from a microfluidic chip into an analytical/collection device. The device can act as an electrospray interface device or as a subatmospheric delivery of a sample to a collection device.

    Inventors: Barry Karger, Frantisek Foret, Daniel Kirby
    US Patent No.: 6,068,749

  • Electro-neumatic Distributor for Multiplexed ยต-Tas Devices

    The technology is a plastic electro-pneumatic distributor assembly used in conjunction with electrospray mass spectrometry. The distributor's purpose is to supply simultaneous electric current and pressurized gas where needed in microfabricated devices.

    Inventors: Barry Karger, Frantisek Foret
    US Patent Application No.: 60/115,107
    Canadian Patent Application No.: 2,357,623

  • Electrochemical Synthesis and Processing of Conducting Polymers in Supercritical Media

    An environmentally benign, safe and inexpensive method of synthesizing conductive polymers such as polyaniline electrochemically in near-critical or supercritical solvents at relatively low temperatures and pressures.

    Inventor: Patricia Ann Mabrouk
    US Patent No.: 7,247,230

  • A Computational Method for Predicting Protein Interaction Sites

    The invention is an in-vitro method for pinpointing active sites in large molecules.

    Inventors: Mary Jo Ondrechen, Ronald J. Williams, Robert J. Futrelle, Huyuan Terry Yang, Dagmar Ringe, James Clifton, Ihsan Shehadi, Leonel Murga, Jaeju Ko, David Budil, Wenxu Tong
    Non-provisional Patent Application No.: 10/678,756

  • Fluid Nanosplitter Device

    The invention is a fluid splitting device that provides an accurate output fluid flow rate in which the turbulence and mixing at the split point are substantially minimized. The device splits a fluid sample into a low nanoliter aliquot for mass spectrometric analysis or other detection devices. Prototypes have been made and tested.

    Inventors: Paul Vouros, Eric Gangl
    US Patent No.: 6,817,554