Deadlines
  • Proposal: 01/16/2018

Funding

  • Amount: Up to $500,00 per year
  • Duration: Up to 5 years

Scope

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. Specifically, this FOA targets the following area designated as scientific priority by the Blue Ribbon Panel (BRP): Recommendation B. Create a translational science network devoted exclusively to immunotherapy approaches to treat and prevent adult cancers.  The goal of the network is to foster collaborative team science approaches to accelerate the discover of new immune targets and evaluate novel immune-based therapies and combination approaches that eliminate established cancers in adults or to prevent cancers before they occur.

The purpose of this FOA is to establish a Cancer Immunotherapy Consortium (CIC) composed of organ site-specific Cancer Immunotherapy Research Projects as a component of the Immuno-Oncology Translation Network (IOTN). The CIC will form an integrated network of multi-disciplinary, collaborative teams with the overarching goals of accelerating translational research of innate and adaptive immune mechanisms that contribute to tumor progression, and evaluating new or improved immunotherapeutic strategies (including combinations with standard or other therapies) resulting in durable anti-cancer responses. Studies should be largely pre-clinical involving clinically-relevant models and endpoints.

The ultimate goal is to evaluate new or improved immunotherapy and combination interventional approaches identified through basic investigation of the mechanisms that contribute to immunosuppressed tumor microenvironments or resistance to immunotherapeutic regimens targeting unfavorable innate and/or adaptive immune functions. Studies should lead to the discovery of vulnerabilities that could be exploited to improve design of immunotherapies, including cancer vaccines, checkpoint inhibitors, cellular therapies, viral therapies, bispecific antibodies, and their combinations with other targeted interventions and/or radiation therapy for durable anti-tumor responses. Basic and pre-clinical studies utilizing clinically-relevant models and clinical specimens to enable rapid, efficient translation of these discoveries into future early-phase clinical evaluations are requested, although clinical trials are not supported through this FOA. The proposed pre-clinical studies may include analysis of human specimens that are delinked from patient identity but well-annotated with clinical information, and correlation of pre-clinical study results with available clinical information.

Contact Information

Scientific/Research Contact(s) – see RFP for other Sponsoring Agency contacts

Nancy Boudreau, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-6702
Email: nancy.boudreau@nih.gov

Minkyung (Min) Song, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-6139
Email: songm@mail.nih.gov