Publications and Patents

Access our publications on PubMed

  1. Ochiana, S.O.; Bland, N.D.; Settimo, L.; Campbell, R.K.; Pollastri, M.P. Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei. Chemical Biology & Drug Design. In Press
  2. Silva, L.; Tanner, A.; Merritt, C.; Stuart, K.; Pollastri, M.P. Protein kinases as druggable targets in protozoan parasites. Chemical Reviews, In Press. Invited review.
  3. Diaz, R.; ºLuengo-Arratta, S.A.; ºSeixas, J.D.; ºAmata, E.; Devine, W.; Cordon-Obras, C.; Rojas-Barros, D.I.; Jimenez, E.; Ortega, F.; Crouch, S.; Colmenarejo, G.; Fiandor, J.M.; Martin, J.J.; Berlanga, M.; Gonzalez, S.; Manzano, P.; Navarro, M.; Pollastri, M.P. Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign. PLOS Neglected Tropical Diseases. In Press.
  4. Parks, A.J.; Pollastri, M.P.; Hahn, M.E.; Stanford, E.A.; Franks, D.G; Haigh, S.E.; Narasimhan, S.; ºAshton, T.D.; Hopper, T.G.; Kozakov, D.; Beglov, D.; Vajda, S.; Schlezinger, J.J.; Sherr, D.H. In Silico Identification of an Aryl Hydrocarbon Receptor (AhR) Antagonist with Biological Activity In Vitro and In Vivo. Molecular Pharmacology. In press.
  5. ºAmata, E.; Bland, N.D.; Hoyt, C.T.; Settimo, L.; Campbell, R.K.; Pollastri, M.P. Repurposing human PDE4 inhibitors for neglected tropical diseases: Design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors. Bioorganic and Medicinal Chemistry Letters. In press.
  6. Gaun, V.; Patchen, B.; Volovetz, J.; Zhen, A.W.; Andreev, A.; Pollastri, M.P.; Fraenkel, P.G. A chemical screen identifies small molecules that regulate hepcidin expression. Blood Cells, Molecules and Diseases 2014, In press.
    http://www.ncbi.nlm.nih.gov/pubmed/24998898
  7. Galvin, B.D.; Li, Z.; Villemaine, E.; Poole, C.B.; Chapman, M.S.; Pollastri, M.P.; Wyatt, P.G.; Carlow, C.K.S. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. PLOS Neglected Tropical Diseases 2014, 8, e3145
    http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0003145
  8. Pollastri, M.P. Finding New Collaboration Models for Enabling Neglected Tropical Disease Drug Discovery. PLoS-Neglected Tropical Diseases 2014, 8, e2866.
    http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002866
  9. ºSeixas, J.D.; ºLuengo-Arratta, S.A.; Diaz, R.; Saldivia, M.; Rojas-Barros, D.I.; Manzano, P.; Gonzalez, S.; Berlanga, M.; Smith, T.K.; Navarro, M.; Pollastri, M.P. Establishment of a structure-activity relationship of the NVP-BEZ235 chemotype as a lead for African sleeping sickness. Journal of Medicinal Chemistry 2014, 57, 4834-4848.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099174/
  10. ºPatel, G.; Roncal, N.E.; Lee, P.J.; Leed, S.E.; Erath, J.; Rodriguez, A.; Sciotti, R.J.; Pollastri, M.P. Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery. MedChemComm  2014, 5, 655 – 658.
    http://www.ncbi.nlm.nih.gov/pubmed/24910766
  11. Lowe, M.M.; Mold, J.E.; Kanwar, B.; Huang, Y.; Louie, A.; Hahn, M.E.; Pollastri, M.P.; ºWang, C.; ºPatel, G.; Frank, D.G.; Schlezinger, J.; Sherr, D.; Silverstone, A.E.; McCune, J.M. Identification of an Endogenous Aryl Hydrocarbon Receptor Ligand That Drives Th22 Differentiation. PLoS One 2014, 9, e87877.
  12. Woodring, J.L.;  Bland, N.D.; Ochiana, S.O.; Campbell, R.K.; Pollastri, M.P. Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Bioorg. Med. Chem. Lett.2013, 23, 5971
    http://www.ncbi.nlm.nih.gov/pubmed/24042005
  13. Patel, G.; Karver, C.E.; Behera, R.; Guyett, P.; Edwards, P.; Roncal, N.E.; Mensa-Wilmot, K.; Pollastri, M.P. Kinase scaffold repurposing for neglected disease drug discovery: Discovery of an efficacious, lapatanib-derived lead compound for trypanosomiasis. J. Med. Chem.2013 http://pubs.acs.org/doi/abs/10.1021/jm400349k

  14. Andriani, G.; Amata, E.; Beatty, J.; Clements, Z.; Coffey, B.J.; Courtemanche, G.; Devine, W.; Erath, J.; Juda, C.E.; Wawrzak, Z.; Wood, J.; Lepesheva, G.I.; Rodriguez, A.; Pollastri, M.P. Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth. J. Med Chem. 2013, 56, 2556 http://dx.doi.org/10.1021/jm400012e
  15. Katiyar, S.; Kufareva, I.; Behera, R.; Ogata, Y.; Pollastri, M.P.; Abagyan, R;. Mensa-Wilmot, K. Lapatinib-binding Protein Kinases in the African Trypanosome: A General Method for Identification of Targets for Kinase-Directed Drugs in a Cell. PloS One, 2013, 8, e56150.
  16. Ochiana, S.O.; Pandarinath, V.; Wang, Z.; Kapoor, R.; Ondrechen, M.J.; Ruben, L.; Pollastri, M.P. The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing. Eur. J. Med. Chem. 2013, 62, 777-784.
  17. Wang, C.; Ashton,  T.D.; Gustafson, A.; Bland, N.D.; Ochiana, S.O.; Campbell, R.K.; Pollastri, M.P. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. 1. Sildenafil analogs. Bioorg. Med. Chem. Lett. 2012. http://dx.doi.org/10.1016/j.bmcl.2012.01.119
  18. Ochiana, S.O.; Gustafson, A.; Bland, N.D.; Wang, C.; Russo, M.J.; Campbell, R.K.; Pollastri, M.P. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. 2. Tadalafil analogs. Bioorg. Med. Chem. Lett. 2012.  http://dx.doi.org/10.1016/j.bmcl.2012.01.118
  19. Bland, N. D.; Wang, C.; Tallman, C.; Gustafson, A. E.; Wang, Z.; Ashton, T. D.; Ochiana, S. O.; McAllister, G.; Cotter, K.; Fang, A. P.; Gechijian, G.; Garceau, N.; Gangurde, R.; Ortenberg, R.; Ondrechen, M. J.; Campbell, R. K.; Pollastri, M. P. Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness. J. Med. Chem. 2011 54, 8188-8194.
  20. Diaz-Gonzalez, R.; Kuhlmann, F.M.; Galan-Rodriguez, C.; Madeira da Silva,L.; Karver, C.E.; Beverley, S.M.; Rodriguez,  A.; Navarro, M; Pollastri, M.P. “The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.” PLoS-Neglected Tropical Diseases 2011, 5, e1297
  21. Shaw, B. F.; Arthanari, H.; Narovlyansky, M.; Durazo, A.; Frueh, D.P.; Pollastri, M. P.; Lee, A.; Bilgicer, B.; Gygi, S. P.; Wagner, G.; Whitesides, G. M. “Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.” J. Am. Chem. Soc. 2010 132, 17411-17425.
  22. Pollastri, M. P.; Whitty, A.; Merrill, J. C., Tang, X. Ashton, T. D.; Amar, S.  “Identification and Characterization of Kava-derived Compounds Mediating TNF-α Suppression.” Chem. Biol. Drug Design 2009, 74, 121-128
  23. Bazin, M; Shi, H; Delaney, J.; Kline, B;, Zhu, Z.; Kuhn, C.; Berlioz, F.; Farley, K.; Fate, G.; Lam, W.; Walker, G.; Yu, L.; Pollastri, M.P. “Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine”, Chem. Biol. Drug Design, 2007, 70, 354-359.
  24. Pollastri, M.P., Sagal, J.F., Chang, G., “The Conversion of Alcohols to Halides Using a Filterable Phosphine Source”, Tetrahedron Letters 2001, 35, 2459-2460.
  25. Pollastri, M.P., Porter, N.A., McIntosh, T.J., Simon, S.A., “Synthesis, Structure, and Thermal Properties of 1,2-Dipalmitoylgalloylglycerol (DPGG), A Novel Self-Adhering Lipid”, Chemistry and Physics of Lipids 2000, 104, 67-74.
  26. McIntosh, T.J., Pollastri, M.P., Porter, N.A., Simon, S.A, “Polyphenols increase adhesion between lipid bilayers by forming interbilayer bridges”, Basic Life Sci. 66(Plant Polyphenols 2) 1999, 451-470.
  27. Jones, P.B., Pollastri, M.P., Porter, N.A., “2-Benzoylbenzoic Acid: A Photolabile Mask for Alcohols and Thiols.”  Journal of Organic Chemistry 1996, 61, 9455-9461.
  28. Curran, T.P., Pollastri, M.P., Abelleira, S.M., Messier, R.J., McCollum, T.A., Rowe, C.G., “Loss of the tert-Butyloxycarbonyl (Boc) Protecting Group Under Basic Conditions.” Tetrahedron Letters 1994, 35, 5409-5412.
  29. Curran, T.P., Smith, M.B., Pollastri, M.P., “Cis-3,5-Dimethyl-3,5-Piperdinedicarboxylic Acid, An Amino Diacid Variant of Kemp’s Triacid.” Tetrahedron Letters 1994, 35, 4515-4518.

Patents

  1. Sherr, D.S., Pollastri, M.P., Schlezinger, J., Haigh Molina, S.E., Schaus, S.E., Giguere, J.R. “Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics.” PCT/US11/45526
  2. Pollastri, M.P., Navarro, M., Beverley, S., Rodriguez, A. “Antiparasitic agents based on mTOR inhibitors” PCT/US11/43557
  3. Chang, G., Didiuk, M. T. Finneman, J. I., Garigiapati, R. S., Kelley, R. M., Perry, D. A., Ruggeri, R. B., Bechle, B. M., Pollastri, M. P. “Preparation of 1,2,4-substituted-1,2,3,4-tetrahydro-and 1,2-dihydroquinoline and 1,2,3,4-tetrahydroquinoxaline derivatives as cetp inhibitors for the treatment of atherosclerosis and obesity.” WO 2004085401.