Publications and Patents

For full text versions of some of these manuscripts, see: http://works.bepress.com/mpollastri

Publications

  1. Woodring, J.L.;  Bland, N.D.; Ochiana, S.O.; Campbell, R.K.; Pollastri, M.P. Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Bioorg. Med. Chem. Lett.2013, 23, 5971
  2. Patel, G.; Karver, C.E.; Behera, R.; Guyett, P.; Edwards, P.; Roncal, N.E.; Mensa-Wilmot, K.; Pollastri, M.P. Kinase scaffold repurposing for neglected disease drug discovery: Discovery of an efficacious, lapatanib-derived lead compound for trypanosomiasis. J. Med. Chem.2013 http://pubs.acs.org/doi/abs/10.1021/jm400349k
  3. Andriani, G.; Amata, E.; Beatty, J.; Clements, Z.; Coffey, B.J.; Courtemanche, G.; Devine, W.; Erath, J.; Juda, C.E.; Wawrzak, Z.; Wood, J.; Lepesheva, G.I.; Rodriguez, A.; Pollastri, M.P. Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth. J. Med Chem. 2013, 56, 2556 http://dx.doi.org/10.1021/jm400012e
  4. Katiyar, S.; Kufareva, I.; Behera, R.; Ogata, Y.; Pollastri, M.P.; Abagyan, R;. Mensa-Wilmot, K. Lapatinib-binding Protein Kinases in the African Trypanosome: A General Method for Identification of Targets for Kinase-Directed Drugs in a Cell. PloS One, 2013, 8, e56150.
  5. Ochiana, S.O.; Pandarinath, V.; Wang, Z.; Kapoor, R.; Ondrechen, M.J.; Ruben, L.; Pollastri, M.P. The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing. Eur. J. Med. Chem. 2013, 62, 777-784.
  6. Wang, C.; Ashton,  T.D.; Gustafson, A.; Bland, N.D.; Ochiana, S.O.; Campbell, R.K.; Pollastri, M.P. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. 1. Sildenafil analogs. Bioorg. Med. Chem. Lett. 2012. http://dx.doi.org/10.1016/j.bmcl.2012.01.119
  7. Ochiana, S.O.; Gustafson, A.; Bland, N.D.; Wang, C.; Russo, M.J.; Campbell, R.K.; Pollastri, M.P. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. 2. Tadalafil analogs. Bioorg. Med. Chem. Lett. 2012.  http://dx.doi.org/10.1016/j.bmcl.2012.01.118
  8. Bland, N. D.; Wang, C.; Tallman, C.; Gustafson, A. E.; Wang, Z.; Ashton, T. D.; Ochiana, S. O.; McAllister, G.; Cotter, K.; Fang, A. P.; Gechijian, G.; Garceau, N.; Gangurde, R.; Ortenberg, R.; Ondrechen, M. J.; Campbell, R. K.; Pollastri, M. P. Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness. J. Med. Chem. 2011 54, 8188-8194.
  9. Diaz-Gonzalez, R.; Kuhlmann, F.M.; Galan-Rodriguez, C.; Madeira da Silva,L.; Karver, C.E.; Beverley, S.M.; Rodriguez,  A.; Navarro, M; Pollastri, M.P. “The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.” PLoS-Neglected Tropical Diseases 2011, 5, e1297
  10. Shaw, B. F.; Arthanari, H.; Narovlyansky, M.; Durazo, A.; Frueh, D.P.; Pollastri, M. P.; Lee, A.; Bilgicer, B.; Gygi, S. P.; Wagner, G.; Whitesides, G. M. “Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.” J. Am. Chem. Soc. 2010 132, 17411-17425.
  11. Pollastri, M. P.; Whitty, A.; Merrill, J. C., Tang, X. Ashton, T. D.; Amar, S.  “Identification and Characterization of Kava-derived Compounds Mediating TNF-α Suppression.” Chem. Biol. Drug Design 2009, 74, 121-128
  12. Bazin, M; Shi, H; Delaney, J.; Kline, B;, Zhu, Z.; Kuhn, C.; Berlioz, F.; Farley, K.; Fate, G.; Lam, W.; Walker, G.; Yu, L.; Pollastri, M.P. “Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine”, Chem. Biol. Drug Design, 2007, 70, 354-359.
  13. Pollastri, M.P., Sagal, J.F., Chang, G., “The Conversion of Alcohols to Halides Using a Filterable Phosphine Source”, Tetrahedron Letters 2001, 35, 2459-2460.
  14. Pollastri, M.P., Porter, N.A., McIntosh, T.J., Simon, S.A., “Synthesis, Structure, and Thermal Properties of 1,2-Dipalmitoylgalloylglycerol (DPGG), A Novel Self-Adhering Lipid”, Chemistry and Physics of Lipids 2000, 104, 67-74.
  15. McIntosh, T.J., Pollastri, M.P., Porter, N.A., Simon, S.A, “Polyphenols increase adhesion between lipid bilayers by forming interbilayer bridges”, Basic Life Sci. 66(Plant Polyphenols 2) 1999, 451-470.
  16. Jones, P.B., Pollastri, M.P., Porter, N.A., “2-Benzoylbenzoic Acid: A Photolabile Mask for Alcohols and Thiols.”  Journal of Organic Chemistry 1996, 61, 9455-9461.
  17. Curran, T.P., Pollastri, M.P., Abelleira, S.M., Messier, R.J., McCollum, T.A., Rowe, C.G., “Loss of the tert-Butyloxycarbonyl (Boc) Protecting Group Under Basic Conditions.” Tetrahedron Letters 1994, 35, 5409-5412.
  18. Curran, T.P., Smith, M.B., Pollastri, M.P., “Cis-3,5-Dimethyl-3,5-Piperdinedicarboxylic Acid, An Amino Diacid Variant of Kemp’s Triacid.” Tetrahedron Letters 1994, 35, 4515-4518.

Patents

  1. Sherr, D.S., Pollastri, M.P., Schlezinger, J., Haigh Molina, S.E., Schaus, S.E., Giguere, J.R. “Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics.” PCT/US11/45526
  2. Pollastri, M.P., Navarro, M., Beverley, S., Rodriguez, A. “Antiparasitic agents based on mTOR inhibitors” PCT/US11/43557
  3. Chang, G., Didiuk, M. T. Finneman, J. I., Garigiapati, R. S., Kelley, R. M., Perry, D. A., Ruggeri, R. B., Bechle, B. M., Pollastri, M. P. “Preparation of 1,2,4-substituted-1,2,3,4-tetrahydro-and 1,2-dihydroquinoline and 1,2,3,4-tetrahydroquinoxaline derivatives as cetp inhibitors for the treatment of atherosclerosis and obesity.” WO 2004085401.