Function of Molecular Chaperon GroEL Follows the Iterative Annealing Mechanism

When: Thursday, October 10, 2013 at 4:00 pm
Where: DA 114
Speaker: Dave Thirumalai
Organization: University of Maryland, College Park
Sponsor: Physics Colloquium

I will describe the annealing function of molecular chaperones using the bacterial chaperone as an example. Using theoretical arguments and simple simulations I will describe how these machines rescue substrate proteins that otherwise aggregate. The resulting Iterative Annealing Mechanism (IAM) is similar to the more familiar simulating annealing used in computer simulations although it has evolved in nature long ago. Quantitative comparison between predictions of IAM with experiments will be made.

Host: Assistant Professor Paul Whitford