Nanoparticles for Biomedical Imaging and Image-Guided Surgery

When: Friday, October 05, 2012 at 1:00 pm
Where: CSC 340
Speaker: Dr. Hak Soo Choi
Organization: Assistant Professor of Medicine, Center for Molecular Imaging, Beth Israel Deaconess Medical Center
Sponsor: IGERT Nanomedicine Seminar

“Nanoparticles hold promise as biomedical imaging, diagnostic, and theragnostic agents. However, the key to
their success hinges on a detailed understanding of their behavior after administration to the body.
Biodistribution, target binding, and clearance are a complex function of their physicochemical properties in
serum, which include hydrodynamic diameter, solubility, stability, shape and flexibility, surface charge,
composition, and formulation. Moreover, many materials used to construct nanoparticles have real or
potential toxicity, or may interfere with other medical tests. In this talk, we discuss the design considerations
that mediate nanoparticle behavior in the body and the fundamental principles that govern clinical
translation. By analyzing nanomaterials that have already received regulatory approval, most of which are
actually therapeutic agents, we attempt to predict which types of nanoparticles hold potential as diagnostic
agents for biomedical imaging and imageguided surgery. ”