Vladimir P. Torchilin
Distinguished ProfessorDirector, Center for Pharmaceutical Biotechnology and Nanomedicine
Office: 211/214 The Fenway
Ph.D., D.Sc., M.S., Moscow State University
Physiologically Active Compounds
Major Research Areas
Drug Delivery Sytems
Experimental Cancer Immunology
The efficacy of drug carriers (including liposomes) can be improved by coating them with certain polymers, thus making them long-circulating. Their properties might be still further improved when they are made targeted by attachment of a target-specific antibody. We are conducting an active research on such long-circulating and targeted pharmaceutical carriers for drugs and diagnostics in a variety of in vitro and in vivo models. II. Many pharmaceutical micelles easily dissociate in vivo. We proposed to use amphiphilic polyethyleneglycol-lipid conjugates for preparing stable polymeric micelles for non-covalent incorporation and delivery of sparingly soluble drugs and diagnostic agents, and are currently investigating very interesting properties of these micelles in vitro and in vivo. III. We have shown that certain non-pathogenic anti-nuclear autoantibodies with nucleosome-restricted specificity are uniquely reactive against the surface of most tumor but not normal cells. Further studies revealed strong anti-tumor potential of these antibodies towards broad spectrum of tumors. Being used intravenously in normal physiological concentrations, monoclonal antibody 2C5 dramatically inhibits aggressive EL4 T cell lymphoma and B16 melanoma in mice. We study currently the mechanism of mAb 2C5 action which seems to be connected with an antibody-mediated cellular cytotoxicity.
V.P.Torchilin, A.N.Lukyanov, Z.Gao, B.Papahadjopoulos-Sternberg, Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs, Proc. Natl. Acad. Sci. USA, 100, 6039-6044, 2003.
V.P.Torchilin, L.Z.Iakoubov, Z.Estrov, Therapeutic potential of antinuclear autoantibodies in cancer, Cancer Therapy, 1, 179-190, 2003.
V.P.Torchilin, Targeted polymeric micelles for delivery of poorly soluble drugs, Cell. Molec. Life Sci., 61, 2549-2559, 2004.
V.P.Torchilin, Recent advances with liposomes as pharmaceutical carriers, Nature Rev. Drug Discov., 4, 145-160, 2005.
B.Gupta, T.Levchenko, V.P.Torchilin, Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides, Adv. Drug Deliv. Rev., 57, 637-651, 2005.