Roger W. Giese
Professor of Chemistry and Biomedical ScienceDirector, Environmental Cancer Research Program
Senior Faculty Fellow, Barnett Institute
Editor, Journal of Chromatography
Contact Information
Office: 202 The Fenway
Voice: 617.373.3227
Fax: 617.373.8720
Email: r.giese@neu.edu
Education
Ph.D., MIT (Cambridge, MA)
B.S., Hamline University
Certification
Diplomate, American Board of Clinical Chemistry
Specializations
Analytical Chemistry
Mass Spectrometry
Environmental Analysis
Major Research Areas
Clinical Diagnostics
DNA Adducts
The research projects in Dr. Giese's laboratory combine aspects of analytical chemistry, organic chemistry and biochemistry to make advances in the reagents and techniques available for trace organic analysis. Emphasis is placed on the development of new methodology for high sensitivity and multi-analyte detection, applied especially to human samples. The principle detection technique being used for high sensitivity is mass spectrometry. Examples of analytes of interest are DNA adducts (damage to genes by carcinogens), steroids, and environmental contaminants. Potentially some of these measurements may help to individualize cancer prevention.
Publications
Zhang, X., Linxiao, X., Wang, P., Wang, Z., Giese, R.W. Synthesis of Releasable Electrophore Tags for Applications in Mass Spectrometry, Bioconjugate Chemistry13, 1002-1012 (2002)
Li, G., Gao, J., Zhou X., Shimelis, O., Giese, R.W. Handling and detection of 25 amol of near-infrared dye deoxynucleotide conjugates by capillary electrophoresis with laser-induced fluorescence detections, J. Chromatogr. A, 1004,47-50 (2003)
Shimelis O., Zhou, W., Li, G., Giese, R.W. Phenolic extraction of DNA from mammalian tissues and conversion to deoxyribonucleoside-5?-monophosphates devoid of irbonucleotides, J. Chromatogr.A., 1053, 143-149 (2004)
Kao, C-Y., Giese, R.W. (2005) Measurement of N7-(2'-hydroxyethyl)guanine in Human DNA by Gas Chromatography Electron Capture Mass Spectrometry, Chem. Res. Toxicol. 18, 70-75(2005)
Giese, R.W. (2003) Measurement of endogenous estrogens: analytical challenges and recent advances, J. Chromatogr. A, 1000, 401-412.
Murugaiah, V., Naim, A., Peng, S., Cui, G., Giese, R. W. (2006) 4-(4'-Methyltetrafluorophenyl)-2,3,5,6-tetrafluorobenzyl bromide: A new electrophoric derivatizing reagent, J. Chromatogr. A, 1134, 338-340
Yong, L. C., Schulte, P.A., Kao, C-K., Giese, R.W., Boeniger, M. F., Strauss, G. H.S., Peterson, M. R., Wiencke, J. K. (2007) DNA Adducts in Granulocytes of Hospital Workers Exposed to Ethylene Oxide, Am. J. Ind. Med., 50, 293-302.09