Kevin CashDr. Kevin Cash Receives the 2012 Ruth L. Kirschstein National Research Service Awards (F32) from NIBIB/NIH
Dr. Kevin Cash, a Post-doctoral Associate working in the laboratory of Heather Clark in the Department of Pharmaceutical Sciences and collaborating with Lihong Wang at Washington University in St. Louis received the 2012 Davis Foundation Fellowship in the amount of $159,102 over three years. Dr. Cash’s project entitled “Nanosensors for in Vivo Photoacoustic Monitoring of Drug Concentrations” focuses on development of nanosensors for the continuous monitoring of lithium concentrations, particularly in the therapy of those affected by bipolar disorder.
Bipolar disorder affects approximately 2.6% of the population and lithium is one of the most commonly used management treatments as it drastically reduces suicide risk. Unfortunately, lithium has a narrow therapeutic window and a low toxic dose. The proposed research is to develop lithium selective nanosensors which can be used for continuous monitoring of lithium concentrations in vivo as well as coupling these nanosensors with both fluorescent and photoacoustic imaging. This research will enable improved study of individualized pharmacokinetics and personalized medicine. Additionally, this research will set the groundwork for a wide range of future investigations utilizing the combination of photoacoustics and nanosensors. These include: monitoring metabolic profiles in tumors which are too deep to measure with fluorescence or drug concentration profiling in the brain and other organs.
The specific aims of this research are to:
1) Develop and characterize absorbance and fluorescence based nanosensors for lithium detection and characterize in vitro
2) Demonstrate in vivo application of nanosensors using fluorescence imaging for monitoring subcutaneous lithium concentrations
3) Couple lithium nanosensors with photoacoustic microscopy to monitor blood lithium concentrations.
This research couples together the Clark laboratory’s experience with nanosensor development and testing with the photoacoustic microscopy experience of Lihong Wang’s laboratory. The proposed research and training plan enable improved study of individualized pharmacokinetics and personalized medicine will provide ample training in both research techniques as well as career development which will leave Dr. Cash well placed for a future as an independent investigator in biomedical research.