Publications and Presentations
PresentationsAmiji, M., Keynote Presentation at the 2011 GRASP Annual Meeting, Massachusetts College of Pharmacy and Health Sciences, Boston, MA. “Multifunctional Nanosystems for Molecular Medicine”. June, 2011.
Amiji, M., Fox Chase Cancer Center, Philadelphia, PA. “Multifunctional Nanosystems to Overcome Tumor Drug Resistance”. July, 2011.
Amiji, M., 2011 Annual National Cancer Institute’s Nanotechnology in Cancer Alliance’s Principal Investigators Meeting, Tutorial Presentation, Boston, MA. “Nucleic Acid Therapeutics: Using DNA and Small Interfering RNA for Cancer”. September 2011.
Amiji, M., 2011 Annual National Cancer Institute’s Nanotechnology in Cancer Alliance’s Principal Investigators Meeting, Boston, MA. “Taming the Beast: Nanotechnology Solutions for Tumor Aggression” September, 2011.
Amiji, M., Eight Lohmann Therapie Systems (LTS) Academy Meeting, Bonn, Germany. “Multi-functional Nanomedicines: From Diagnostics to Targeted Delivery”. September, 2011.
Amiji, M., Indiana University, Department of Biochemistry and Molecular Biology, Indianapolis, IN. “Multi-functional Nanomedicines: From Cancer Diagnostics to Targeted Delivery”. October, 2011.
Amiji, M., University of Missouri at Columbia, Oncology Grand Rounds, Columbia, MO. “Multi-functional Nanomedicines: From Cancer Diagnostics to Targeted Delivery”. October, 2011.
Amiji, M., American Association of Pharmaceutical Scientists (AAPS) 2012 annual meeting. Special symposium on “Nano-Delivery Systems for Vaccines”. Washington, DC. “Multi-Compartmental Delivery Systems for Cancer Vaccination”. October, 2011.
2011 Society for Neuroscience Meeting, Washington, D.C. "Development of a non-viral vector for GDNF gene therapy of Parkinson's disease", B. T. HARMON, D. YUREK, M. COOPER, L. PADEGIMAS, K. DINES, R. LORING, B. WASZCZAK, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C."Progress toward developing an intranasal gene therapy approach to CNS disorders". B. HARMON, A. NADEAU, L. WANG, M. MIGLIORE, M. COOPER, B. L. WASZCZAK, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C."Evidence for additional α7 nicotinic receptor chaperones in GH4C1 cells after knocking down rat Ric3 protein", T. KOPERNIAK, B. GARG, J. BOLTAX, R. LORING, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C. "Autism in Oman: Nutritional deficiencies in vitamin B12 and folate associated with gender-specificabnormalities in serum thiol levels". N. HODGSON, M. I. WALY, Y. M. AL-FARSI, R. C. DETH, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C. "Redox signaling in human brain and its implications for drug addiction". R.C. DETH, M.S. TRIVEDI, and N. W. HODGSON, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C. "Casein and gluten-derived peptides modulate cysteine uptake and cellular thiol levels via activation ofopiate receptors". M. S. TRIVEDI, N. W. HODGSON, R. C. DETH, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C. "Blocking recall of conditioned fear in an animal model of PTSD with a V1a receptor antagonist". C. F. FERRIS, B. SMERKERS, N. SIMON, November, 2011
2011 Society for Neuroscience Meeting, Washington, D.C. "Novel vasopressin 1a antagonists for CNS disorders: Development and characterization of clinical candidates". N. G. SIMON, K. FABIO, C. GUILLON, S.-F. LU, M. J. BROWNSTEIN, C. F. FERRIS, N. D. HEINDEL, November, 2011
2011 AAPS National Biotechnology Conference, San Francisco, CA Tao Wang, Valery A Petrenko, and Vladimir P Torchilin. Landscape phage fusion protein self-assembled with pharmaceutical nanocarriers for targeted and cytoplasmic delivery of chemotherapeutics to breast cancer cells. Podium presentation.
2011 AAPS annual meeting and Exposition. Washington, DC Tao Wang, Valery A Petrenko, and Vladimir P Torchilin. Formulation Development of PEG -PE Micelles Modified with Breast Cancer MCF-7 Cell-Specific Phage fusion Protein for Optimization of Targeted Delivery of Poorly-Soluble Paclitaxel.
2011 AAPS annual meeting and Exposition. Washington, DC. Tao Wang, Valery A Petrenko, and Vladimir P Torchilin. The targeted specificity of phage fusion protein-modified liposomes: only the binding peptide motif is involved.
AAPS Northeast Regional Meeting, Rocky Hill, CT, 2011. Tao Wang, Valery A Petrenko, and Vladimir P Torchilin. Landscape phage fusion protein self-assembled with pharmaceutical nanocarriers for targeted and cytoplasmic delivery of chemotherapeutics to breast cancer cells.
TechConnect World Conference and Expo 2011, Boston, MA, 2011. Tao Wang, Valery A Petrenko, and Vladimir P Torchilin. Landscape Phage Fusion Protein Self-assembled with Pharmaceutical Nanocarriers for Targeted and Cytoplasmic Delivery of Chemotherapeutics to Breast Cancer Cells.
The 31st annual meeting of Graduate Research Association of Student in Pharmacy (GRASP). Boston, MA, 2011. Tao Wang, Valery A Petrenko, and Vladimir P Torchilin. Landscape Phage Fusion Protein Self-assembled with Pharmaceutical Nanocarriers for Targeted and Cytoplasmic Delivery of Chemotherapeutics to Breast Cancer Cells.
38th Annual Meeting and Exposition of the Controlled Release Society 2011, National Harbor, MD J.Upponi, V.Torchilin, Development and Characterization of Micellar Theranostic Agent for Simultaneous Magnetic Resonance Imaging and Cancer Therapy. Abstract # 72. 38th Annual Meeting and Exposition of the Controlled Release Society 2011, National Harbor, MD. (Podium presentation) # 72.
31st Annual Graduate Research Association of Students in Pharmacy (GRASP) meeting 2011, Boston, MA. Jaydev R. Upponi, Kaushal Jerajani, Dattatri K. Nagesha, Praveen Kulkarni, Srinivas Sridhar, Craig Ferris and Vladimir P. Torchilin. Lipid-base Micellar Theranostic Agent for Simulaneous Magnetic Resonance Imaging and Cancer Therapy: Development and Characterization. Abstract # PM26.
Jaydev R. Upponi, Kaushal Jerajani, and Vladimir P. Torchilin. Lipid-base Micellar Theranostic Agent for Simulaneous Magnetic Resonance Imaging and Cancer Therapy: Development and Characterization. Abstract RPP # 18. 14th Annual AAPS - Northeast Regional Discussion Group (NERDG) meeting 2011, Rocky Hill, CT.
Northeastern University 5th Annual Pharmsci Research Schowcase 2011, Boston, MA. T. Musacchio, J. Upponi, W. Hartner, T. Levchenko, S. Siavoshi, C. Yalmiz, A. Busnaina, V.P. Torchilin. Antibody-Coated Polystyrene Beads Assembled on Microchips to serve as Biosensors for highly sensitive Immunoassays of Cancer Markers: Test with anti-CEA mAb. Abstract # 10
Northeastern University 5th Annual Pharmsci Research Schowcase 2011, Boston, MA. Jaydev R. Upponi, Kaushal Jerajani, Dattatri K. Nagesha, Praveen Kulkarni, Srinivas Sridhar, Craig Ferris and Vladimir P. Torchilin. Development and Characterization of a Lipid-base Micellar Theranostic Agent for Simulaneous Magnetic Resonance Imaging and Cancer Therapy. Abstract # 14.
Northeastern University Expo 2011, Boston, MA Jaydev R. Upponi, Kaushal Jerajani and Vladimir P. Torchilin. Polymeric Micellar Theranostic Agent for Simultaneous Magnetic Resonance Imaging and Cancer Therapy: Development and Characterization. Abstract # 2043. Northeastern University Expo 2011, Boston, MA
Northeastern University Expo 2011, Boston, MA J.R. Upponi, T. Musacchio, W.C. Hartner, T.S. Levchenko, S. Siavoshi, C. Yalmiz, A. Busnaina, V.P. Torchilin.Antibody-Coated Polystyrene Beads Assembled on Microchips as Biosensors for highly sensitive Immunoassays of Cancer Markers: Test with anti-CEA mAb. Abstract # 14.
Nanotech Conference (June 15th 2011 at Boston) Anjali Apte, Erez Koren, Vladimir Torchilin Multifunctional liposomes for enhanced tumor targeting
Poster for GRASP Conference, June 11th 2011, Boston) Anjali Apte, Erez Koren, Vladimir Torchilin. Multifunctional 2C5-immunoliposomes containing pH-sensitive bonds and PEGylated TAT peptide for enhanced cellular internalization by tumor cells.
NCI Alliance for Nanotechnology in Cancer Annual Principle Investigators' Meeting, 2011, Boston Combination Anticancer Nanopreparations of Novel Proapoptotic Drugs and TRAIL Ligand
38th Controlled Release Society meeting, National Harbor, Maryland, 2011. S. Biswas, R. R. Sawant, N.S. Dodwadkar, V.P. Torchilin. Reversible Attachment of Specific Ligands to Liposomes: Synthesis and In vitro Characterization.
S.Biswas, R. R. Sawant, N. S. Dodwadkar, V. P. Torchilin. Liposome Targeting to Mitochondria Using Novel PEG-PE-Based Polymer with Terminal Triphenylphosphonium Group.
Book Chapters
Iftimia, N., Amiji, M., Milane, L., and Oldenburg, A. Nanotechnology approaches for contrast enhancement in optical imaging and disease targeted therapy. In Iftimia, N., Brugge, W., and Hammer, D.X (Eds.). Advances in Optical Imaging for Clinical Medicine, Chapter 16. Wiley Publishing, New York, NY. 2011. Chapter 16, pp 455-504.
Shahiwala, A., Vyas, T.K., and Amiji, M.M. Nanotechnology for targeted delivery of drugs and genes. In Nalwa, H.S. (Ed.). Encyclopedia of Nanoscience and Nanotechnology, 2nd Edition, American Scientific Publishers, New York, NY. 2011. Volume 19, pp 265-295.
Kalariya, M., Ganta, S., Attarwala, H., and Amiji, M. Multifunctional lipid nano-systems for cancer prevention and therapy. In Souto, E. (ed.). Advanced Anticancer Approaches with Multifunctional Lipid Nanocarriers. iSmithers Rapra Publishing, Inc., Billingham, UK. 2011. Chapter 3, pp 29-54.
Biswas S, Vaze OS, Mova S, Torchilin VP. “Polymeric micelles for delivery of poorly soluble drugs. Drug delivery strategies for poorly water soluble drugs. (2011). Ed: Fahr, A & Douroumis D. London. John Wiley and Sons. (Manuscript submitted)
Peer-Reviewed Papers
Kriegel, C. and Amiji, M. Dual TNF-β/Cyclin D1 gene silencing using an oral microparticle system as a novel strategy for the treatment of inflammatory bowel disease. Clinical and Translational Gastroenterology, Published Online, DOI:10.1038/ctg.2011.1 (2011).
Milane, L., Ganesh, S., Shah, S., Duan, Z., and Amiji, M. Multi-modal strategies for overcoming tumor drug resistance: hypoxia, Warburg’s effect, stem cells, and multifunctional nanotechnology. Journal of Controlled Release, Published Online, DOI :10.1016/j.jconrel.2011.03.032 (2011).
das Neves, J., Amiji, M., and Sarmento, B. Mucoadhesive nanosystems for vaginal microbicide development: friend or foe? WIREs Nanomedicine and Nanobiotechnology, Published Online, DOI:10.1002/wnan.144 (2011).
das Neves, J., Bahia, M.F., Amiji, M., and Sarmento, B. Mucoadhesive nanomedicines: measurement and modulation of mucoadhesion at the nanoscale. Expert Opinion on Drug Delivery, Published Online, DOI: 10.1517/17425247.2011.586334 (2011).
Xu, J., Ganesh, S., and Amiji, M. Non-condensing polymeric nanoparticles for targeted gene and siRNA delivery. International Journal of Pharmaceutics, Published Online, DOI: 10.1016/j.ijpharm.2011.05.036 (2011).
Abeylath, S.C., Ganta, S., Iyer, A., and Amiji, M. Combinatorial-designed multifunctional polymeric nanosystems for tumor-targeted therapeutic delivery. Accounts of Chemical Research, Published Online, DOI: 10.1021/ar2000106 (2011).
Milane, L., Duan, Z., and Amiji, M.M. Therapeutic efficacy and safety of combination paclitaxel/ lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant breast cancer. PLoS ONE, 6(9): e24075. (2011). DOI:10.1371/journal.pone.0024075.
Deshpande, D.D., Janero, D.R., and Amiji, M.M. Therapeutic strategies for endothelial dysfunction. Expert Opinion on Biological Therapy, 11(12): 1637-1654 (2011). DOI: 10.1517/14712598.2011.625007.
Abeylath, S.C. and Amiji, M.M. “Click” synthesis of dextran macrostructures for combinatorial-designed self-assembled nanoparticles encapsulating diverse anticancer therapeutics. Bioorganic and Medicinal Chemistry, 19(21): 6167-6173 (2011). DOI: doi:10.1016/j.bmc.2011.09.024.
das Neves, J., Michiels, J., Ariën, K.K., Vanham, G., Amiji, M.M., Bahia, M.F., and Sarmento, B. Polymeric nanoparticles improve the intracellular delivery, antiretroviral activity and safety of the microbicide drug candidate dapivirine. Pharmaceutical Research, Published Online, DOI: 10.1007/s11095-011-0622-3 (2011).
Peer Reviewed Journal Publications
Tao Wang, Nikita Kulkarni, Deepa Bedi, Gerard GM D’Souza, Papahadjopoulos-Sternberg B, Valery A Petrenko, and Vladimir P Torchilin. J Drug Target. 2011. 19(8): 597-605.
Tao Wang, Jaydev R Upponi, Vladimir P Torchilin. Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies. Int J Pharm. 2011 PMID: 21798324 (In press)
Sawant RR, Vaze OS, Wang Tao, D'Souza GG, Rockwell K, Gada K, Khaw BA, Vladimir P Torchilin. Palmitoyl Ascorbate Liposomes and Free Ascorbic Acid: Comparison of Anticancer Therapeutic Effects Upon Parenteral Administration. Pharm Res. 2011. (In press)
Publications
Hosur V, Loring RH. α4β2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling. Mol Pharmacol. 2011 Jan;79(1):167-74. PMID: 20943775.
Dubach JM, Balaconis, M.K., and Clark, H.A., Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems, Journal of Visualized Experiments, 2011, Jul 4;(53). pii: 2896. PMID: 21750495.
Ozaydin-Ince G, Dubach JM, Gleason KK, Clark H.A., Microworm optode sensors limit particle diffusion to enable in vivo measurements, Proceedings of the National Academy of Science U S A (PNAS), 2011 Feb 15;108(7):2656-61. PMID: 21282619
Balaconis, M.K., Billingsley, K., Dubach JM, Cash, K.J., and Clark, H.A., The design and development of fluorescent nano-optodes for in vivo glucose monitoring, Journal of Diabetes Science and Technology, 2011 Jan 1;5(1):68-75. PMID: 21303627
Dubach, J.M., Zhang, N., Lim, E., Francis, K.P., and Clark, H.A., In vivo sodium concentration continuously monitored with fluorescent sensors, Integrative Biology, 2011 Feb 8;3(2):142-8. PMID: 21088796
Dubach JM, and Clark, H.A., Nanosensors, (contributed book chapter, highlighting sodium dynamics in cardiac cells), 2011, in review.
Cash, K.J., and Clark, H.A., Nanosensors and nanomaterials for monitoring glucose in diabetes, Trends Mol Med. 2010 Dec;16(12):584-93.
“System And Method Enabling Mobile Device To Perform Fluorescent Measurements” by J. Matthew Dubach and Heather Clark; US Patent application, August 2011.
Sawant RR, Vaze OS, Wang T, D’Souza GM, Rockwell K, Gada K, Khaw BA, Torchilin VP. Palmitoyl ascorbate liposomes and free ascorbic acid: Comparison of therapeutic effects upon parenteral administration. Pharm Res. 2011, Aug 16. (Manuscript accepted-in press)
Sawant RR, Vaze OS, D'Souza GG, Rockwell K, Torchilin VP. Palmitoyl ascorbate-loaded polymeric micelles: cancer cell targeting and cytotoxicity. Pharm Res 2011, 28(2):301-308.
Wang, T.; Upponi, J.R.; Torchilin, V.P. Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies. Int. J. Pharm. 2011, doi:10.1016/j.ijpharm.2011.07.013.
Salome Siavoshi, Cihan Yilmaz, Sivasubramanian Somu, Tiziana Musacchio, Jaydev R. Upponi, Vladimir P. Torchilin, Ahmed Busnaina. Size-Selective Template-Assisted Electrophoretic Assembly of Nanoparticles for Biosensing Applications. Langmuir 2011 27 (11), 7301-7306
Aristarchos Papagiannaros, Jaydev Upponi, William Hartner, Dmitriy Mongayt, Tatyana Levchenko and Vladimir Torchilin. Quantum dot-loaded immunomicelles for tumor imaging. BMC Medical Imaging 2010, 10:22doi:10.1186/1471-2342-10-22
Asanterabi Malima, Ahmed Busnaina, Salome Siavoshi, Sivasubramanian Somu, Cihan Yilmaz, Tiziana Musacchio, Jaydev Upponi, Vladimir Torchilin. Multi-Biomarkers Biosensors. USPTO Application # 20110117582 – Class: 435 792 (USPTO)
Jaydev R. Upponi, Kaushal Jerajani, Dattatri K. Nagesha, Praveen Kulkarni, Srinivas Sridhar, Craig Ferris and Vladimir P. Torchilin. Lipid-based Micellar Theranostic Agent for Simultaneous Magnetic Resonance Imaging and Cancer Therapy: Development and Characterization. (manuscript submitted to Future Medicine:Nanomedicine)
A.Koshkaryev, R.Thekkedath, C.Pagano, I.Meerovich, V.P.Torchilin, Targeting of lysosomes by liposomes modified with octadecyl-rhodamine B. J. Drug Target., 19, 606-614, 2011.
I.Meerovich, A.Koshkaryev, R.Thekkedath, V.Torchilin, Screening and optimization of ligand conjugates for lysosomal targeting, Bioconj. Chem., 2011.
Koren, E., Apte, A., Sawant, R. R., Grunwald, J., and Torchilin, V. P. Cell-penetrating TAT peptide in drug delivery systems: Proteolytic stability requirements, Drug Deliv, (2011), 377-384.
Swati Biswas, Namita S. Dodwadkar, Rupa R. Sawant, Alexander Koshkaryev, and Vladimir P. Torchilin. Surface modification of liposomes with rhodamine-123-conjugated polymer results in enhanced mitochondrial targeting Journal of Drug Targeting 2011 19:7, 552-561
Swati Biswas, Namita S. Dodwadkar, Rupa R. Sawant, and Vladimir P. Torchilin. Development of the Novel PEG-PE-Based Polymer for the Reversible Attachment of Specific Ligands to Liposomes: Synthesis and in Vitro Characterization Bioconjugate Chemistry 2011 22 (10), 2005-2013
Navarro, G., R. Sawant, Essex S. et al. Phospholipid–polyethylenimine conjugate-based micelle-like nanoparticles for siRNA delivery. Drug Delivery and Translational Research 2011, 1(1): 25-33.
Navarro G, Sawant RR, Biswas S, Essex S, Tros de Ilarduya C, Torchilin VP. P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells. Nanomedicine 2011. doi:10.2217/NNM.11.93 In Press