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A new age for drug development

In a new research paper, North­eastern fac­ulty mem­bers dis­cuss the ana­lyt­ical chal­lenges researchers face as biosim­i­lars take center stage in phar­ma­ceu­tical development.

Jones and Engen

Northeastern opens Waters Center of Innovation

North­eastern Uni­ver­sity hosted a ribbon-​​​​cutting cer­e­mony on Wednesday to com­mem­o­rate the new home of the Waters Lab­o­ra­tory at 140 The Fenway. The lab, des­ig­nated as a Waters Center of Innovation, […]


Collaborating to fight cancer with knowledge

North­eastern and the Dana-​​Farber Cancer Insti­tute have announced an insti­tu­tional col­lab­o­ra­tion to fight cancer by lever­aging each institution’s expertise.

Jones and Engen

Neutralizing HIV function

North­eastern pro­fessor John R. Engen is part of an inter­dis­ci­pli­nary, multi-​​institutional research team that recently pub­lished a paper on HIV anti­bodies in the journal Nature Struc­tural & Mol­e­c­ular Biology.

April 13, 2015 - John Engen, Professor of Bioanalytical Chemistry and Faculty Fellow in the Barnett Institute of Chemical and Biological Analysis.

Northeastern researchers gain a voice in federal drug policy

Chem­istry chair’s tes­ti­mony at FDA hearing advances University’s role in for­mu­lating U.S. approach to intro­duc­tion of new biopharmaceuticals

No limit” on this undergraduate’s future

Chem­istry major coau­thors paper on cancer treat­ment in Nature mag­a­zine and earns plau­dits from his research mentor at Dana-​​Farber Cancer Institute

The future of drug development

Chem­istry pro­fessor is advancing novel methods for ana­lyzing a spe­cific family of pro­teins that play a key role in the cre­ation of new biopharmaceuticals

Researcher receives prestigious American Chemical Society award

North­eastern pro­fessor John Engen has been rec­og­nized by the ACS for his achieve­ments and research con­tri­bu­tions as a young ana­lyt­ical scientist.

Selected Publications

For a complete list of faculty citations, please visit iRis, Northeastern’s digital archive.


Antibody mechanics on a membrane-bound HIV segment essential for gp41-targeted viral neutralization

(with Kim, M., Sun, Z.-Y. J., Rand, K. D., Shi, X., Song, L., Cheng, Y., Fahmy, A. F., Majumdar, S., Ofek, G., Yang, Y., Kwong, P. D., Wang, J.-H., Wagner, G. & Reinherz, E. L. ) Nat. Struct. Mol. Biol. 18(11), 1235-1243.


Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

(with Morgan, C. R., Hebling, C. M., Rand, K. D., Stafford, D. W., and Jorgenson, J. W.) Mol. Cell. Proteomics 10(9), M111.010876.


On the solution conformation and dynamics of the HIV-1 Viral Infectivity Factor

(with Marcsisin, S. R., Narute, P. S., Emert-Sedlak, L. A., Kloczewiak, M., and Smithgall, T. E.) J. Mol. Biol. 410(5), 1008-1022.

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