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From protein signaling to cancer drug development
For decades, the inner workings of a protein implicated in the cause of nearly 30 percent of all cancers baffled drug developers. But chemistry professor Carla Mattos may have unlocked the mystery.
Selected Publications
For a complete list of faculty citations, please visit iRis, Northeastern’s digital archive.
Analysis of binding site hot spots on the surface of Ras GTPase
(with Buhrman, G., O’Connor, C., Zerbe, B., Kearney, B. M., Napoleon, R., Kovrigina, E. A., Vajda, S., Kozakov, D., and Kovrigin, E. L.) Journal of Molecular Biology, 413, 773-789 (2011).
Allosteric modulation of Ras-GTP is linked to signal transduction through Raf kinase
(with Burhman, G., Kumar, S., Cirit, M., and Haugh, J. M.) Journal of Biological Chemistry, 286, 3323-3331 (2011).
Allosteric modulation of Ras positions Q61 for a direct role in catalysis
(with Buhrman, G., Holzapfel, G., and Fetics, S.) PNAS, 107, 4931-4936 (2010).
