Select Publications

Diem, M.; Miljković, M.; Bird, B.; Chernenko, T.; Schubert, J.; Marcsisin, E. J.; Mazur, A. I.; Kingston, E.; Zuser, E.; Papamarkakis, K.; Laver, N., Applications of Infrared and Raman Micro-spectroscopy of Cells in Medical Diagnostics: Present Status and Future Promise. Spectroscopy – Biomedical Applications 2012, (26), (In Press).

Marcsisin, E. J.; Uttero, C. M.; Mazur, A. I.; Miljković, M.; Bird, B.; Diem, M., Noise Adjusted Principal Component Reconstruction to Optimize Infrared Microspectroscopy of Individual Live Cells. Analyst 2012, (In Press).

Diem, M; Laver, N.; Bedrossian, K.; Schubert, J.; Papamarkakis, K.; Bird, B.; Miljković, M.,  “Detection of Viral Infection in Epithelial Cells by Infrared Spectral Cytopathology”, Handbook of Biophotonics, Popp, J., Ed, Wiley, Vol. 2, Chap 17, pp 251-261.

Bird, B.; Miljković, M.; Laver, N.; Diem, M., “Spectral Detection of Micro-Metastases and Individual Metastatic Cells in Lymph Node Histology”, (2011Techn. Cancer Res. Treatment (TCRT)10(2), 135-144.

Matthäus, C.; Chernenko, T.; Miljković, M.; Quintero, L.; Amiji, M.; Torchilin, V.; Diem, M., “Raman Micro-spectral Imaging of Cells, and Applications Monitoring the Uptake of Drug Delivery Systems”, in “Confocal Raman Imaging”, Hollricher and Dieing, Ed, Springer Verlag, Heidelberg, Germany, 2011, 137-162.

Whelan, D. R.; Bambery, K. R.; Heraud, P.; Tobin, M. J.; Diem, M.; McNaughton, D.; Wood, B. R., Monitoring the reversible B to A-like transition of DNA in eukaryotic cells usint Fourier transform Infrared spectroscopy. Nucleic Acids Research 2011, 39, (13), 5439-5448.

Mazur, A. I.; Marcsisin, E. J.; Bird, B.; Miljković, M.; Diem, M., Evaluating Different Fixation Protocols for Spectral Cytopathology, Part I. Analytical Chemistry 2012, 84, 1259-1266.

Lin, C. Y.; Suhalim, J. L.; Nien-Shy, C.; Miljković, M.; Diem, M.; Jester, J. V.; Potma, E. O., Picosecond spectral CARS imaging with principal component analysis of meibomian glands. J. Biomed. Optics 2011, 16, (2), 1-9.

Hedegaard, M.; Matthäus, C.; Hassing, S.; Krafft, C.; Diem, M.; Popp, J., Spectral unmixing and clustering algorithms for assessment of single cells by Raman microscopic imaging. Theor. Chem. Acc. 2011, 130, 1249-1260.

Cherchi, C.; Chernenko, T.; Diem, M.; Gu, A. Z., Impact of Nano Titanium Dioxide Exposure on Cellular Structure of Anabaena Variabilis and Evidence of Internalization. Environmental Toxicology and Chemistry 2011, 30, (4), 861-869.

Chernenko, T.; Sawant, R.; Matthäus, C.; Quintero, L.; Torchilin, V.; Diem, M.,  “A Novel Approach to Follow the Intracellular Fate of Pharmaceutical Nanocarriers”, (2010) Controlled Release Newsletter, 27(3), 18-19.

Zuser, E.; Chernenko, T.; Newmark, J.; Miljković, M.; Diem, M., Confocal Raman microspectral imaging (CRMI) of murine stem cell colonies. Analyst 2010, 135, (12), 3030-3033.

Schubert, J. M.; Mazur, A. I.; Bird, B.; Miljković, M.; Diem, M., Single point vs. mapping approach for spectral cytopathology (SCP). J Biophotonics 2010, 3, (9), 588-596.

Schubert, J. M.; Bird, B.; Papamarkakis, K.; Miljković, M.; Bedrossian, K.; Laver, N.; Diem, M., Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells. Lab Invest 2010, 90, (7), 1068-1077.

Quintero, L.; Miljković, M.; Hunt, S.; Matthäus, C.; Diem, M., Impulsive Noise Reduction in Raman Spectroscopy Images. Proc. of SPIE 2010, 7568.

Quintero, L.; Matthäus, C.; Hunt, S.; Diem, M., Denoising Single Scan Raman Spectroscopy Signals. Proc. of SPIE 2010, 7568.

Papamarkakis, K.; Bird, B.; Schubert, J. M.; Miljković, M.; Wein, R.; Bedrossian, K.; Laver, N.; Diem, M., Cytopathology by optical methods: spectral cytopathology of the oral mucosa. Lab Invest 2010, 90, (4), 589-598.

Miljković, M.; Chernenko, T.; Romeo, M. J.; Bird, B.; Matthäus, C.; Diem, M., Label-free imaging of human cells: algorithms for image reconstruction of Raman hyperspectral datasets. Analyst 2010, 135, (8), 2002-2013.

Mariani, M. M.; Maccoux, L. J.; Matthäus, C.; Diem, M.; Hengstler, J. G.; Deckert, V., Micro-Raman detection of nuclear membrane lipid fluctuations in senescent epithelial breast cancer cells. Anal Chem 2010, 82, (10), 4259-63.

Marcsisin, E. J.; Uttero, C. M.; Miljković, M.; Diem, M., Infrared microspectroscopy of live cells in aqueous media. Analyst  2010, 135, (12), 3227-32.

Bird, B.; Miljković, M.; Diem, M., Two step resonant Mie scattering correction of infrared micro-spectral data: human lymph node tissue. J Biophotonics 2010, 3, (8-9), 597-608.

Majed, N.; Matthäus, C.; Diem, M.; Gu, A. Z., Evaluation of intracellular polyphosphate dynamics in enhanced biological phosphorus removal process using Raman microscopy. Environ Sci Technol 2009, 43, (14), 5436-5442.

Diem, M.; Papamarkakis, K.; Schubert, J.; Bird, B.; Romeo, M. J.; Miljković, M., The infrared spectral signatures of disease: extracting the distinguishing spectral features between normal and diseased states. Appl Spectrosc 2009, 63, (11), 307A-318A.

Diem, M.; Matthäus, C.; Chernenko, T.; Romeo, M. J.; Miljković, M.; Bird, B.; Schubert, J.; Papamarkakis, K.; Laver, N., Chapter 5: Infrared and Raman Spectroscopy and Spectral Imaging of Individual Cells. In Infrared and Raman Spectroscopic Imaging, Salzer, R.; Sielsler, H.W., Eds. WILEY VCH & Co.: 2009.

Chernenko, T.; Matthäus, C.; Milane, L.; Quintero, L.; Amiji, M.; Diem, M., Label-free Raman spectral imaging of intracellular delivery and degradation of polymeric nanoparticle systems. ACS Nano 2009, 3, (11), 3552-3559.

Matthäus, C.; Chernenko, T.; Milane, L.; Kale, A.; Quintero, L.; Amiji, M.; Torchilin, V.; Diem, M., “Raman Microscopy Imaging of Nanocarrier Systems for Cellular Uptake and Trafficking”, (2009) Controlled Release Newsletter, 26(1), 13-14.

Bird, B.; Romeo, M.; Laver, N.; Diem, M., Spectral detection of micro-metastases in lymph node histo-pathology. J Biophotonics 2009, 2, (1-2), 37-46.

Bird, B.; Bedrossian, K.; Laver, N.; Miljković, M.; Romeo, M. J.; Diem, M., Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging. Analyst 2009, 134, (6), 1067-76.

Wood, B. R.; Chernenko, T.; Matthäus, C.; Diem, M.; Chong, C.; Bernhard, U.; Jene, C.; Brandli, A. A.; McNaughton, D.; Tobin, M. J.; Trounson, A.; Lacham-Kaplan, O., Shedding new light on the molecular architecture of oocytes using a combination of synchrotron Fourier transform-infrared and Raman spectroscopic mapping. Anal Chem 2008, 80, (23), 9065-72.

Romeo, M. J.; Boydston-White, S.; Matthäus, C.; Miljković, M.; Bird, B.; Chernenko, T.; Lasch, P.; Diem, M., Chapter 2: Infrared and Raman Microspectroscopic Studies of Individual Human Cells. In Vibration Spectroscopy for Medical Diagnosis, John Wiley & Sons, Ltd.: 2008.

Romeo, M. J.; Dukor, R. K.; Diem, M., Chapter 1: Introduction to Spectral Imaging, and  Applications to Diagnosis of Lymph Nodes. In Vibrational Spectroscopy for Medical Diagnosis, John Wiley & Sons, Ltd.: 2008.

Romeo, M.; Boydston-White, S.; Matthäus, C.; Miljković, M.; Bird, B.; Chernenko, T.; Diem, M., Chapter 6: Vibrational Microspectroscopy of Cells and Tissues. In Biomedical Vibrational Spectroscopy, John Wiley & Sons, Inc: 2008.

Matthäus, C.; Kale, A.; Chernenko, T.; Torchilin, V.; Diem, M., New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy. Mol Pharm 2008, 5, (2), 287-93.

Matthäus, C.; Chernenko, T.; Quintero, L.; Milan, L.; Kale, A.; Amiji, M.; Torchilin, V.; Diem, M., Raman Microscopic Imaging of Cells and Applications Monitoring the Uptake of Drug Delivery Systems. Proc. SPIE 2008, 6991, 06/1-06/8.

Matthäus, C.; Bird, B.; Miljković, M.; Chernenko, T.; Romeo, M.; Diem, M., Chapter 10: Infrared and Raman microscopy in cell biology. Methods Cell Biol . Volume 89: Biophysical Tools for Biologists, Volume 2”, Edited by J.J. Correia and H.W. Detrich, III, Elsevier-Academic Press, Amsterdam, The Netherlands, 2008, 89, 275-308.

Bird, B.; Romeo, M. J.; Diem, M.; Bedrossian, K.; Laver, N.; Naber, S., Cytology by Infrared Micro-Spectroscopy: Automatic Distinction of Cell Types in Urinary Cytology. Vib Spectrosc 2008, 48, (1), 101-106.

Bird, B.; Miljković, M.; Romeo, M. J.; Smith, J.; Stone, N.; George, M. W.; Diem, M., Infrared micro-spectral imaging: distinction of tissue types in axillary lymph node histology. BMC Clin Pathol 2008, 8.