Publications

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Peer-Reviewed Journal Publications (Either Accepted or Published; Graduate student author)

Gathungu,R., Oldham, J.T., Lee-Parsons, C. W.T., Vouros, P., Kautz, R. (2011) “An integrated LC-MS-NMR platform for the identification of benzophenanthridine alkaloids from the California poppy”, Journal of Analytical Methods, 4: 1315-1325.

Shulman, M., Cohen, M., Soto-Gutierrez, A., Yagi, H., Wang H., Goldwasser, J., Lee-Parsons, C. W., Benny-Ratsaby, O., Yarmush, M. L., Nahmias, Y.  (2011) “Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin,” PLoS ONE, 6(4):  e18033.

Oldham, J.T., Hincapie, M., Rejtar, T., Wall, P.K., Carlson, J.E., Lee-Parsons, C. W.T. (2010) “Shotgun proteomic analysis of yeast-elicited California poppy (Eschscholzia californica) suspension cultures producing enhanced levels of benzophenanthridine alkaloids,” Journal of Proteomic Research, 9:  4337–4345.

Goklany, S., Loring, R.H., Glick, J., Lee-Parsons, C. W.T. (2009) “Assessing the limitations to terpenoid indole alkaloid biosynthesis in Catharanthus roseus hairy root cultures through gene expression profiling and precursor feeding,” Biotechnology Progress, 25(5):  1289-1296.

Cho,H.-Y., Son, S.Y., Rhee, H.S., Yoon, S.-Y. H., Lee-Parsons, C. W.T., Park, J.M. (2008) “Synergistic effects of sequential treatment with methyl jasmonate, salicylic acid and yeast extract on benzophenanthridine alkaloid accumulation and protein expression in Eschscholzia californica suspension cultures,” Journal of Biotechnology, 135(1):  117-122.

Lee-Parsons, C. W.T., (2007) Gas composition strategies for the successful scale-up of Catharanthus roseus cell cultures for the production of ajmalicine,” Phytochemistry Reviews, 6(2-3):  419-433.

Cho,H.-Y., Lee-Parsons, C. W.T., Yoon, S.-Y. H., Rhee, H.S., Park, J.M. (2007) “Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholzia californica suspension cultures,” Biotechnology Letter, 29(12):  2001-5.

Lee-Parsons, C. W.T. & Royce, A.J. (2006) “Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell cultures,” Plant Cell Reports, 25:  607-612.

Lee-Parsons, C. W.T. & Ertürk, S. (2005) “Ajmalicine production in methyl jasmonate-induced Catharanthus roseus cell cultures depends on Ca2+ level,” Plant Cell Reports, 24(11):  677-682.

Lee-Parsons, C. W.T. (2005) “Biochemical engineering taught in the context of drug discovery to manufacturing,” Chemical Engineering Education, 39(3):  208-215, 221.

Lee-Parsons, C. W.T. & Shuler, M.L. (2005) “Sparge gas composition affects biomass and ajmalicine production from immobilized cell cultures of Catharanthus roseus,Enzyme and Microbial Technology, 37(4):  424-434.

Lee-Parsons, C. W.T., Ertürk, S., & Tengtrakool, J. (2004) “Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation,” Biotechnology Letters, 26(20):  1595-1599.

Wong, P.L., Royce, A.J., & Lee-Parsons, C. W.T. (2004) “Improved ajmalicine production and recovery from Catharanthus roseus suspensions with increased product removal rates,” Biochemical Engineering Journal, 21(3):  253-258.

Lee-Parsons, C. W.T. & Shuler, M.L. (2002) “The effect of ajmalicine spiking and resin addition timing on the production of indole alkaloids from Catharanthus roseus cell cultures,” Biotechnology and Bioengineering, 79(4):  408-415.

Lee, C. W.T. (2000) “Guiding principles for teaching:  distilled from my first few years of teaching,” Chemical Engineering Education, 34(4):  344-345, 349.

Lee, C. W.T. & Shuler, M.L. (2000) “The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Catharanthus roseus cells,” Biotechnology and Bioengineering, 67(1):  61-71.

Taticek, R.A., Lee, C. W.T., & Shuler, M.L. (1994) “Large-scale insect and plant cell culture,” Current Opinion in Biotechnology, 5:  165-174.  R.A. Taticek authored the insect cell culture review; C. W.T. Lee authored the plant cell culture review.

Lee, C. W.T. & Shuler, M.L. (1991) “Different shake flask closures alter gas phase composition and ajmalicine production in Catharanthus roseus cell suspensions,” Biotechnology Techniques, 5(3):  173-178.

  • Contact

    Dr. Carolyn W. T. Lee-Parsons
    Department of Chemical Eng.
    313 Snell Engineering Center
    Northeastern University
    360 Huntington Avenue
    Boston, MA 02115

    Email: ca.lee@neu.edu
    Phone: (617) 373-3634
    Fax: (617) 373-2209