An estimated one million people in the United States currently have a positive HIV status. Over the last few decades, many improvements have been made in the testing, treatment, and prevention of HIV, but the people most at-risk for contracting the virus do not always have access to these services. Blacks and African Americans represent the largest proportion of any race that has HIV positive status, and Hispanics suffer from the disease at a rate disproportionate to their population in the United States. Social inequalities and power asymmetry in gender relations can contribute to the likelihood of contracting the HIV virus. In addition, exposure to violence, unstable housing, and drug use also increase an individual’s risk for exposure to HIV. At the Institute on Urban Health Research and Practice (IUHRP), scholars work with high risk populations to create programs that target effective HIV prevention practices. Currently, the Institute is involved in a grant that is working to reduce urban women’s HIV risk using soap opera videos on smart phones.