Transcriptional Control of Alkaloid Biosynthesis in Catharanthus roseus Cultures
The vision of this research is to address the need for an alternative supply of critical plant-derived pharmaceuticals using plant cell cultures. Increasing the volumetric productivity of these pharmaceuticals from plant cell cultures will reduce the cost of the drug to the patient and enable a dependable supply of the drug. In addition, the PI/Co-PI will 1) incorporate concepts and examples from their research into their courses and develop new lab modules, 2) co-advise graduate students and undergraduates in interdisciplinary research that applies biochemical engineering, genetic engineering, and molecular biology approaches to this research, and 3) support K-12 STEM education by hosting teachers and students through hands-on research experiences in their laboratory.
Northeastern University’s College of Engineering is home to numerous federally-funded research centers and an array of leading-edge projects and initiatives that advance discovery and new knowledge in health, sustainability, and security.