Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
This project will result in development of a novel, natural matrix-based cell delivery vehicle for delivery of retinal progenitor cells (RPCs) to the subretinal space to promote retinal regeneration and restoration of visual function in patients suffering from retinopathies including macular degeneration and retinopathy of prematurity. While the strategy of progenitor cell delivery to the subretinal space has demonstrated hugely promising results, including some vision rescue, major barriers to success are low levels of RPC integration (<1%) into host retina and high levels of RPC death. Here, the natural structural and biochemical cues provided by native interphotoreceptor matrix (IPM) will be used to promote RPC survival and integration into adjacent host retina.
Northeastern University’s College of Engineering is home to numerous federally-funded research centers and an array of leading-edge projects and initiatives that advance discovery and new knowledge in health, sustainability, and security.