B.Sc., Biology, Moscow University, Moscow, USSR
Ph.D., Biochemistry, Moscow University, Moscow, USSR
Area(s) of Expertise
The focus of my research is on antimicrobial drug tolerance and drug discovery. Microorganisms produce persister cells, which are dormant variants that are highly tolerant to killing by all known antibiotics. Persisters are largely responsible for relapsing chronic infections caused by biofilms. Using transcriptome analysis, cell sorting and whole genome sequencing we are identifying genes responsible for persister formation. Both drug tolerance and conventional drug resistance require development of new antibiotics, and our discovery efforts include screening compounds from previously “uncultured” species of microorganisms, and high-throughput screening for compounds with novel mode of action.
306C Mugar Life Sciences Building
3Qs: A new path to curing chronic Lyme disease
University Distinguished Professor of Biology Kim Lewis is exploring alternative approaches to curing chronic Lyme disease using his expertise in bacterial cell persistence.
Researchers discover new treatment to cure MRSA infection
University Distinguished Professor of Biology Kim Lewis and his team have published a study that presents a novel approach to treat and eliminate MRSA.
Report shows Northeastern spinoffs help fuel economic growth
Three Northeastern spinoff companies were highlighted in a recent report by The Science Coalition as examples of how federally funded university research and the companies created from that work can boost the U.S. economy.
Study: Antibiotics are unique assassins
In recent years, a body of publications in the microbiology field has challenged all previous knowledge of how antibiotics kill bacteria.