Ph.D., Biochemistry, Moscow University, Moscow, USSR
B.Sc., Biology, Moscow University, Moscow, USSR
Area(s) of Expertise
The focus of my research is on antimicrobial drug tolerance and drug discovery. Microorganisms produce persister cells, which are dormant variants that are highly tolerant to killing by all known antibiotics. Persisters are largely responsible for relapsing chronic infections caused by biofilms. Using transcriptome analysis, cell sorting and whole genome sequencing we are identifying genes responsible for persister formation. Both drug tolerance and conventional drug resistance require development of new antibiotics, and our discovery efforts include screening compounds from previously “uncultured” species of microorganisms, and high-throughput screening for compounds with novel mode of action.
306C Mugar Life Sciences Building
A research team led by University Distinguished Professor Kim Lewis presents in a new paper that it has identified drug-tolerant persister cells in the bacterium that causes Lyme disease. The researchers also present a promising approach to potentially eradicating this and other infections.
Born from soil, the novel compound made possible by Northeastern researchers’ pioneering work is making headlines around the world and receiving applause from the science community.