Kim Lewis

University Distinguished Professor; Director, Antimicrobial Discovery Center Email: k.lewis@neu.edu Phone: 617.373.8238

Degrees/Education

B.Sc., Biology, Moscow University, Moscow, USSR
Ph.D., Biochemistry, Moscow University, Moscow, USSR

Area(s) of Expertise

Molecular Microbiology

Research Interests

The focus of my research is on antimicrobial drug tolerance and drug discovery. Microorganisms produce persister cells, which are dormant variants that are highly tolerant to killing by all known antibiotics. Persisters are largely responsible for relapsing chronic infections caused by biofilms. Using transcriptome analysis, cell sorting and whole genome sequencing we are identifying genes responsible for persister formation. Both drug tolerance and conventional drug resistance require development of new antibiotics, and our discovery efforts include screening compounds from previously “uncultured” species of microorganisms, and high-throughput screening for compounds with novel mode of action.

Lab Website

Publications

 

Location

306C Mugar Life Sciences Building

3Qs: A new path to curing chronic Lyme disease

University Distinguished Professor of Biology Kim Lewis is exploring alternative approaches to curing chronic Lyme disease using his expertise in bacterial cell persistence.

Researchers discover new treatment to cure MRSA infection

Uni­ver­sity Dis­tin­guished Pro­fessor of Biology Kim Lewis and his team have published a study that presents a novel approach to treat and eliminate MRSA.

Report shows Northeastern spinoffs help fuel economic growth

Three Northeastern spinoff companies were highlighted in a recent report by The Science Coalition as examples of how federally funded university research and the companies created from that work can boost the U.S. economy.

Study: Antibiotics are unique assassins

In recent years, a body of pub­li­ca­tions in the micro­bi­ology field has chal­lenged all pre­vious knowl­edge of how antibi­otics kill bac­teria.