Site Director

Adam Hall

Adam HallDr. Adam Hall is the Director of the Core Mass Spectrometry Facility within the Barnett Institute of Chemical and Biological Analysis – Department of Chemistry and Chemical Biology at Northeastern University. He received a Bachelor’s degree in Chemistry from Stonehill College, a Master’s degree in Chemistry and a PhD in Analytical Chemistry, from Northeastern University. Prior to his academic career, he was employed by the Massachusetts State Police Crime Laboratory as a forensic chemist. His expertise in forensic analytical chemistry is derived from a combination of casework experience, education, research, and consulting opportunities. Over time, the formation of strong collaborations with industry partners has helped to advance forensic research initiatives within the areas of drugs of abuse, toxicology, and ignitable liquid analysis as well as the analysis of energetic materials. Dr. Hall is a board member of the Northeastern Association of Forensic Scientists and a member of the Fire Debris and Explosives subcommittee within the Organization of Scientific Area Committees (OSAC) through the National Institute of Standards and Technology (NIST).

Faculty

Alexander R. Ivanov

Alexander IvanovProfessor Ivanov is an expert in the area of mass spectrometry-based proteomic research. Prof. Ivanov earned his Ph.D. in Bioorganic Chemistry at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow in 2000. He performed his postdoctoral training at Northeastern University prior to joining the Harvard School of Public Health at Harvard University, where he served as Director of the HSPH Proteomics Resource in 2003-2011. Dr. Ivanov re-joined Northeastern as Research Associate Professor at the Barnett Institute in 2011. He has been actively involved in national and international initiatives enabled under the umbrella of the ABRF to develop standards for proteomics research and standardize proteomic practices. For his work in the field of high sensitivity proteomics, Prof. Ivanov was recognized with an ASMS Research Award in 2015.

Prof. Ivanov has a long-standing interest in developing and applying analytical technologies to answer questions and generate new knowledge in biological and clinical studies. Prof. Ivanov’s current research focuses on the following areas: (1) development of techniques for ultra-high sensitivity deep proteomic profiling of limited biological samples; (2) comprehensive characterization of protein isoforms, proteoforms, and modifications (e.g. post-translational modifications, chemical modifications, sequence variants, charge variants), including detailed characterization of biopharmaceuticals; (3) analysis of proteins and protein complexes in their native non-denatured states; (4) isolation and characterization of extracellular vesicles, including circulating exosomes and microparticles, as potential sources of disease biomarkers and vehicles for targeted therapy delivery; (5) large-scale metabolomic, lipidomic, and systems biology studies of complex biological systems.

Proposed Title:
Technology Development for Ultra-High Sensitivity Deep Characterization of Proteins, Protein Complexes, and Proteomes

Carolyn W.T. Lee-Parsons

Carolyn Lee-Parsons, Associate Professor of Chemical Engineering.  Carolyn W.T. Lee-Parsons is an Associate Professor jointly appointed in the Departments of Chemical Engineering and Chemistry & Chemical Biology at Northeastern University. Prior to joining Northeastern in 1999, she was an Assistant Professor of Chemical Engineering at Rose-Hulman Institute of Technology. She received her B.S. from the University of Kansas and her Ph.D. from Cornell University. Her research interests are in biochemical engineering, specifically the production of pharmaceutical compounds and biofuels from plant tissue cultures and microalgae cultures.

Research interests: The research vision of her laboratory is

  1. to enhance the production of valuable, biologically active compounds (i.e. anti-cancer, anti-infectives, and anti-microbials) from plant cell and tissue cultures to meet the need for critical plant-derived pharmaceuticals or therapies and
  2. to improve the oil productivity of microalgae to provide a secure, renewable, and environmentally sustainable source of biofuels.

Towards that vision, my research investigates bottlenecks to production and elucidates fundamental mechanisms underlying the regulation of biosynthesis. Using this fundamental knowledge, we apply genetic engineering and bioprocess engineering strategies to increase the production of these valuable metabolites in a reproducible and scalable tissue culture system.

Title of Presentation: Engineering the Biosynthesis of Medicinal Natural Products from Plant Cell Cultures

Mary Jo Ondrechen

Enzyme ResearchersMary Jo Ondrechen‘s expertise is in the areas of theoretical chemistry, computational biology, and bioinformatics. She received the ACS-certified Bachelor’s degree in Chemistry from Reed College and the Ph.D. degree in Chemistry and Chemical Physics from Northwestern University in Illinois. After postdoctoral research appointments at the University of Chicago and at Tel-Aviv University in Israel, the latter as a NATO Postdoctoral Fellow, she joined the faculty at Northeastern University in Boston, Massachusetts. Currently she serves as Professor of Chemistry and Chemical Biology. She is the Principal Investigator of the Computational Biology Research Group at Northeastern University. Her research deals with understanding enzyme catalysis, genomics, predicting the function of proteins, protein design, and the computational aspects of drug discovery.