Colloquium Schedule: Spring 2013

January 30th

Dr. Christian Goldsmith, Assistant Professor of Chemistry at Auburn University; Auburn, AL

Department Website

Goldsmith Research Group Website

Title: "Designing Coordination Compounds to Tune the Regioselectivity of Alkane Oxidation and Directly Sense Reactive Oxygen Species by MRI"




The talk will discuss two projects that feature rational ligand design as a means of controlling the redox chemistry of transition metal ions. In the first project, an iron complex with a bulky tetradentate ligand is used to guide the regioselectivity of catalyzed C-H activation away from the thermodynamically weakest bonds in alkane substrates. An additional benefit provided by the ligand is that it allows the study of reactive intermediates in the catalyzed oxidation of C-H bonds by O2. In the second project, a redox-active ligand is used to prepare a manganese-containing MRI contrast agent that is capable of detecting H2O2 under physiologically relevant conditions. The reaction with H2O2 couples the mononuclear contrast agent into a binuclear species that is less paramagnetic per Mn(II) ion, reducing the overall relaxivity.

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Updated 01/15/2013