GRADUATE STUDENT ASSOCIATION

Colloquium Schedule: Spring 2011

January 26th

Dr. Suzanne Stokes, Chemistry Principal Scientist I in Infection Discovery Research and Development at AstraZeneca; Waltham, MA

Title: Medicinal chemistry approach to antibacterial DNA ligase inhibitors

 

 

Abstract

There is a growing need for new agents to combat resistant bacteria.  This talk will describe the discovery and optimization of a series of adenosine inhibitors targeting bacterial NAD+-dependent DNA ligase (LigA).   These compounds exhibit antibacterial activity against a range of Gram positive pathogens, including S. pneumoniae and S. aureus.  In vivo efficacy was demonstrated for the first time for LigA, thus validating its potential use as a target for antibacterial therapy.

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