Title: Surface plasmon resonance imaging: where are we now?
Abstract
In this talk I will briefly review recent work from my laboratory using angle-resolved surface plasmon resonance imaging (SPRi) for traditional biosensor applications such as studying DNA interaction kinetics and thermodynamics as well as for other applications such as characterizing how nanoparticle optical properties change near metal surfaces. I will also discuss the pitfalls and difficulties inherent to biosensor measurements as presented in the literature especially for complex protein systems and show unpublished results using 2-color SPR and SPRi applied to the study the tumor necrosis factor TNFalpha/TNF receptor system.