Medicinal Chemistry and Chemical Technology
PhD, Brown University, Providence, RI
MS, Duke University, Durham, NC
AB, College of the Holy Cross, Worcester, MA
Our primary research focus is on discovery of new therapeutics for neglected tropical diseases, using a “parachute” or “repurposing” approach. In this approach, we identify parasitic targets of importance that have been previously biochemically validated, with a further focus on those targets with human homologs that have been pursued in human drug discovery. We then prepare known ligands previously reported against the human homolog for assessment against the parasite target, and then pursue an optimization programfrom that starting point. Our first project is focused on trypanosomal phosphodiesterases, enzymes that have ~30% homology to human PDE4 and 5. Other projects focus on trypansomal TOR, Aurora kinases, dihydrofolate reductase, and HDACs.
Our secondary area of focus is on chemical technologies. Projects in this category include diversification of lead compounds using reaction screening approaches, applications of flow chemistry, and Green Chemistry.