Ira S. Krull
202 Hurtig Hall
1968 Ph.D. , New York University
1966 M.S., New York University
1962 B.S., City College of New York
Professor Emeritus Krull formally retired from Northeastern University as of July 1, 2008, but has remained teaching active thru the fall semester, 08/09. He has taught for the second time, an undergraduate course, Introduction to Forensic Sciences, to about 50 students. At the same time, he has been professionally active in various consulting arrangements, the Massachusetts Separations Society (Massep), and in external training courses for private industry. In the spring semester, he will teach a graduate level course at the Hebrew University of Jerusalem, Israel, for Chemistry, Biochemistry, Biology, and other science or biotechnology majors. He will also instruct in various training courses for industrial firms around the country, thru a national training firm in Ness-Ziona, Israel. Professor Krull will return to Northeastern for the fall semester, 09, and offer an undergraduate and/or graduate course(s) in Chemistry and Chemical Biology. He will continue to edit a series of instructional columns in LCGC Magazine in 2009, dealing with analytical method validation protocols and approaches.
Professor Krull’s research interests are in several areas of analytical biochemistry/biotechnology, especially methods for the analysis and detection of biopolymers and largely emphasize the use of separations methods including HPLC, HPCE, mass spectrometry, and capillary electrochromatography. He has developed, validated, and applied such separation methods for numerous proteins, antibodies, and peptides, of natural and/or recombinant derivation, especially those of commercial interest and medicinal applications. These methods have often been developed and applied in collaboration with industrial colleagues.
At present there are two major areas of research activity. These include efforts to develop: (1) multidimensional HPLC-MS analytical methods for proteins/peptides and proteomics; and (2) planar electrochromatography (PEC) of peptides and proteins, in 1-dimension or 2-dimensions (PEC/TLC) for peptidomics and proteomics, then interfaced with various MS detection approaches. Much of this work has been undertaken together with biotechnology, pharmaceutical and/or instrumentation firms, often using specialized instrumentation available therein.
V. Panchagnula, A. Mikulskis, L. Song, Y. Wang, T. Knubovets, E. Scrivener, E. Golenko, I.S. Krull, M. Schulz, H.E. Hauck, and W. F. Patton. Phosphopeptide analysis by direct coupling two-dimensional planar electrochromatography/thin-layer chromtaography with matrix-assisted laser desorption time-of-flight mass spectrometry. J. Chromatogr., A (2007), 1155, 112.
Millea, K.M.; Krull, I.S.; Chakraborty, A.B.; Gebler, J.C.; Berger, S.J. Comparative profiling of human saliva by intact protein LC/ESI-TOF mass spectrometry. Biochim. Biophys. Acta (2007), 1774(7), 897-906.
Millea, Kevin M.; Krull, Ira S.; Cohen, Steven A.; Gebler, John C.; Berger, Scott J. Integration of Multidimensional Chromatographic Protein Separations with a Combined "Top-Down" and "Bottom-Up" Proteomic Strategy. Journal of Proteome Research (2006), 5(1), 135-146.