![]() | Clinton E. Canal Research Assistant Professor Department: Center for Drug Discovery Department 2: School of Pharmacy Office: 211C Mugar Hall Résumé/CVEmail: c.canal@neu.edu |
Education/degrees:
Ph.D. in Neuroscience, University of Illinois, Urbana-Champaign
B.S. in Psychology, University of Florida
Minor in Philosophy, University of Florida
Research:
function of serotonin systems, e.g. serotonin 2C and serotonin 7 receptors, drug discovery targeting serotonin systems to treat psychiatric disorders, e.g. schizophrenia and depression, neurobiology of psychiatric disorders, pharmacology (molecular, behavioral, and psycho-)
Courses:
PSC G222: The Chemistry and Biology of Drugs of Abuse (Guest lecturer)
Recent Publications:
Canal, C.E., Morgan, D. (2012). Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its current utility as a model. Drug Testing and Analysis. DOI: 10.1002/dta.1333
Cordova-Sintjago, T.C., Sakhuja, R., Kondabolu, K., Canal, C.E., Booth, R.G. (2012) Molecular determinants for ligand binding at serotonin 5-HT2A and 5-HT2C GPCRs: Affinity results analyzed by molecular modeling and ligand docking studies. International Journal of Quantum Chemistry. DOI: 10.1002/qua.24237
Canal, C.E., Cordova-Sintjago, T.C., Villa, N.Y., Fang, L., Booth, R.G. (2011). Drug discovery targeting human 5-HT2C receptors: Residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation. European Journal of Pharmacology. DOI: http://dx.doi.org/10.1016/j.ejphar.2011.10.006
Cordova-Sintjago, T.C., Villa, N.Y., Canal, C.E., Booth, R.G. (2011). Human serotonin 5-HT2C G protein-coupled receptor homology model from the β2 adrenergic receptor structure: ligand docking and mutagenesis studies. International Journal of Quantum Chemistry. DOI: 10.1002/qua.23231