Education/Degrees:

Ph.D. Polymer Chemistry/Drug Delivery Systems, Sojo University, Japan

M.S. Polymer Science, University of Pune, India

B.S. Chemistry, University of Pune, India

Research Interests:

Polymeric Biomaterials

Drug Delivery Systems

Biomedical Imaging

Nanomedical Technologies

Patents:

Mansoor Amiji and Arun Iyer, Multifunctional self-assembling polymeric nanosystems. Provisional US Patent Application, PCT/US2009/060175, WO/2010/042823/EP Patent 2,352,490.

Mansoor Amiji and Arun Iyer,Biodegradable Polymeric Buffers. Provisional US Patent Application, April 2011.

Publications:

Book Chapters:

Khalid Greish, Arun K. Iyer, Fang Jun and Maeda H. Enhanced permeability and retention (EPR) effect and tumor-selective delivery of anticancer drugs in Delivery of protein and peptide drugs in cancer, Vladimir P. Torchilin eds., Imperial college press, London, 37-52 (2006).

Arun Iyer, Srinvas Ganta and Mansoor Amiji.Polymeric Nanoparticles as Target-Specific Delivery Systems, In Handbook of Materials for Nanomedicine, Torchilin V and Amiji M eds. Pan Stanford Series on Biomedical Nanotechnology, World Scientific Publishing Inc., (2009).

Srinvas Ganta, Arun Iyer and Masoor Amiji, Multifunctional Stimuli-Responsive Nanoparticles for Targeted Delivery of Small and Macromolecular Therapeutics. In Targeted Delivery of Small and Macromolecular Drugs, Mahato R. and Narang A. Eds.  CRC press, (2010).

Arun K. Iyer, Shanthi Ganesh, Qionglin Zhou and Mansoor Amiji. Multifunctional Nanosystems for RNA Interference Therapy. In, Manmohan Sigh Eds., Biological Drug Products: Development and Strategies. John Wiley, in press (2012).

Amit Singh, Arun K. Iyer, Srinivas Ganta_, and Mansoor Amiji^. Multifunctional Nano-Systems for Cancer Therapyin  Kinam Park and Laura Overend  Eds, Biomaterials for Cancer Therapeutics: Diagnosis, Prevention and Therapy.Woodhead Publishing Inc., in press(2013).

Amit Singh, Arun K. Iyer and Mansoor M. Amiji. Polymeric Nanosystems for Integrated Image-Guided Therapy in Vladimir P. Torchilin Eds, Frontiers of Nanobiomedical ResearchBook Series, World Scientific Publishing Co, in preparation (2013).

Research publications:

Arun K. Iyer, Amit, Singh, Srinivas Ganta, and Mansoor Amiji. Integrated Multi-Functional Nanosystems to Overcome Tumor Drug Resistance. Adv. Drug Deliv. Rev.in preparation (2013).

Arun K. Iyer, Jiang He and Mansoor Amiji.Image-Guided Nanosystems for Targeted Delivery in Cancer Therapy. Curr. Med. Chem.19(19):3230-3240 (2012).

Nicusor Iftimia, Arun K. Iyer, Daniel X. Hammer,Nyiom Lue, Mircea Mujat, Martha Pitman,and Mansoor Amiji. Fluorescence-guided Optical Coherence Tomography for Colon Cancer Screening:  A Preliminary Mouse StudyBiomed. Opt. Express3:178-191(2012).

Eisuke Kobayashi, Arun K. Iyer, Francis J. Hornicek, Mansoor M. Amiji, and Zhenfeng Duan. Lipid Functionalized Dextran-based Nanosystems to Overcome Multidrug Resistance. Clin. Orthop. Relat. Res. In Press (2012).

Arun K. Iyer, Xiaodong Zhu, Yang Su, Jinjin Feng, Xiaoju Zhang, Youngho Seo, Henry F. Vanbrocklin, Bin Liu and Jiang He. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res., 71(1):2428-2432 (2011).

Arun K. Iyer, Yang Su, Jinjin Feng, Xiaoli Lan, Xiaodong Zhu, Yue Liu, Youngho Seo, Dongwei Gao, Henry F. VanBrocklin, V. Courtney Broaddus, Bin Liu and Jiang He. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma.Biomaterials, 32(10):2605-2613 (2011).

Sampath Abeylath, Srinivas Ganta, Arun K. Iyer and Mansoor Amiji. Combinatorial-Designed Multifunctional Nanosystems for Targeted Therapeutic Delivery. Acc. Chem. Res.44(10),1009–1017 (2011).

Arun K. Iyer and Jiang He. Radiolabeled Oligonucleotides for Antisense Imaging. Curr. Org. Synth. 8(4):604-614(2011).

Michiro Susa*, Arun K. Iyer*,  Keinosuke Ryu, Edwin Choy, Francis J. Hornicek, Henry Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan. Inhibition of ABCB1 (MDR1) expression by SiRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS ONE 5(5):e10764. (*First author equal contribution) (2010).

Jiang He, Yong Wang, Jinjin Feng, Xiaodong Zhu, Xiaoli Lan, Arun K. Iyer, Niu Zhang, Youngho Seo, Henry F. VanBrocklin, Bin Liu. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody. J. Nucl. Med. 51(3):427-432 (2010).

Jun Fang, Takahiro Seki, Haibo Qin, Gahininath Y. Bharate, Arun K. Iyer, Hiroshi Maeda. Tissue Protective Effect of Xanthine Oxidase Inhibitor, Polymer Conjugate SMA-AHPP, on Hepatic Ischemia-Reperfusion Injury. Exp. Biol. Med. 235(4):487-96 (2010).

Jun Fang*, Arun K. Iyer*,  Hideaki Nakamura, Takahiro Seki, Khaled Greish and Hiroshi Maeda. SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect, J. Control. Release135(3): 211-7 (*First author equal contribution)(2009).

Michiro Susa, Arun K. Iyer, Keinosuke Ryu, Francis J. Hornicek, Henry Mankin, Mansoor M. Amiji, Zhenfeng Duan. Doxorubicin Loaded Polymeric Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma. BMC Cancer 9:399 (2009).

Jurstine Daruwalla, Khaled Greish, Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Arun Iyer, Hiroshi Maeda and Chris Christophi. SMA-pirarubicin enhances tumor permeability and disrupts the microvasculature of colorectal liver metastases. J. Vasc. Res. 46(3):218-28 (2009).

Karoline V. Gleixner, Matthias Mayerhofer, Anja Vales, Alexander Gruze, Gregor Hörmann, Veronika Ferenc, Eva Lackner, Emir Hadzijusufovic, Michael Kneidinger, Arun K. Iyer, Maria-Theresa Krauth, Winfried F. Pickl, Brigitte Marian, Renate Panzer-Grünmayer, Christian Sillaber, Hiroshi Maeda, Christoph Zielinski, Peter Valent.  Targeting of Hsp32 in solid tumors and leukemias: A novel approach to optimize anticancer therapy. Curr. Cancer Drug Targets 9(5): 675-89 (2009).

Emir Hadzijusufovic, Laura Rebuzzi, Karoline V. Gleixner, Veronika Ferenc, Rudin Kondo, Alexander Gruze, Michael Kneidinger, Maria-Theresa Krauth, Matthias Mayerhofer, Puchit Samorapoompichit, Khaled Greish,  Arun K. Iyer, Winfried F. Pickl, Hiroshi Maeda, Michael Willmann, Peter Valent. Targeting of heat shock protein 32 (Hsp32)/heme oxygenase 1 (HO-1) in canine mastocytoma cells is associated with reduced growth and induction of apoptosis. Exp. Hematol. 36(11):1461-70 (2008).  

Jun Fang, Dawei Deng, Hideaki Nakamura, Tereo Akuta, Qin Haibo, Arun K. Iyer, Khaled Greish, Hiroshi Maeda. Oxystress inducing antitumor therapeutics via targeted delivery of PEG-conjugated d-amino acid oxidase.Int. J. Cancer 122: 1135-1144, (2008).

Jun Fang, Hideaki Nakamura and Arun K Iyer. Tumor-targeted induction of oxystress for cancer therapy. J. Drug Target.15: 475-486, (2007).

Jurstine Daruwalla, Khaled Greish, Mehrdad Nikfarjam, Ian Millar, Cathy Malcontenti-Wilson, Arun K. Iyer, Chris Christophi. Evaluation of the effect of SMA- pirarubicin micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice. J. Drug Target. 15: 487-495 (2007).

Arun K. Iyer, Khaled Greish, Jun Fang, Ryoichi Murakami and Hiroshi Maeda. High Loading Nanosized micelles of Copoly(Styrene-Maleic Acid)-zinc protoporphyrin for the targeted delivery of a potent heme oxygenase inhibitor. Biomaterials 28 (10): 1871-81 (2007).

Arun K. Iyer, Khaled Greish, Takahiro Seki, Shoko Okazaki, Jun Fang, Keizo Takeshita & Hiroshi Maeda. Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation. J. Drug Target, 15: 496-506 (2007).

Arun K Iyer,Khaled Greish, Jun Fang and Hiroshi Maeda. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov. Today 11(17-18):812-818 (2006).