| Carol Paronis|
Department: Department of Pharmaceutical Sciences
Department 2: School of Pharmacy
Office: 140 TF Rm. 246
Specializations: Behavioral Pharmacology, Neuropharmacology, Drugs of Abuse
Drugs of Abuse
Many drugs are associated with chronic use, yet the consequences of long-term drug exposure on subsequent responses to drugs are not fully understood. My research is primarily concerned with the interplay between pharmacology and behavior in the expression of tolerance to drugs. The acute or chronic effects of drugs are evaluated using behavioral or physiological assays appropriate for the drug class. Behavioral procedures used in my laboratory include operant responding, drug discrimination, and drug self-administration; changes in the physiological responses to drugs are assessed using assays of antinociception, diuresis, or thermal regulation. The goal of this work is to add to our interpretation of pharmacological activity by delineating contextual influences that modify responses to drugs.
Delatte MS and Paronis CA: Evaluation of cannabinoid agonists using punished responding and midazolam discrimination procedures in squirrel monkeys. Psychopharmacology, 2008; 198:521-528.
Bergman J, Delatte, MS, Paronis CA, Vemuri, K, Thakur, GA, Makriyannis, A. Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties. Physiol Behav, 2008; 93:666-670.
Desai RI, Neumeyer JL, Bergman J, Paronis CA. Pharmacological characterization of the effects of dopamine D1 agonists on eye blinking in rats. Behav Pharmacol 2007; 18:745-754.
Bergman J, Paronis CA. Measuring the reinforcing strength of abused drugs. Molecular Interventions 2006; 6(5):271-281.
Gasior M, Bergman J, Kallman MJ, Paronis CA. Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys. Neuropsychopharmacology, 2005; 30:758-764.
Paronis CA, Bergman J. Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys. J Pharmacol Exp Ther 1999; 290:1222-1229