School Offers New Fellowship Program with Cubist
The School of Pharmacy is pleased to announce the launch of a new collaboration with Cubist Pharmaceuticals, Inc., to offer its Post-Doctoral PharmD Pharmaceutical Industry Fellowship Program. Cubist Pharmaceuticals is a biopharmaceutical company that focuses on the research, commercialization and creation of pharmaceutical products that address unmet medical needs in the acute care environment. The fellowship provides PharmD graduates with in-depth experiences in a biopharmaceutical industry setting as well as teaching and research opportunities in an academic/clinical setting. READ MORE
Northeastern Hosts 29th Annual John W. Webb Lecture
Area hospital pharmacists, residents, fellows, faculty, students, and guests were inspired by the words of Ray Maddox, Director of Clinical Pharmacy, Research and Pulmonary Medicine at St. Joseph’s/Candler Health System in Savannah, Georgia. Dr. Maddox was this year’s recipient of the John W. Webb Visiting Professorship in Hospital Pharmacy, selected by a committee appointed by the American Society of Health-System Pharmacists. The theme of his year’s lecture was “The Essence of Leadership” and the day’s events included a roundtable discussion with eight past Webb Lecture Award recipients, and local residents and fellows. READ MORE
Students Celebrate Professionalism
Students, along with their families and guests, gathered to attend the Class of 2017 White Coat Ceremony on November 3, 2013 in Blackman Auditorium. The ceremony, which signifies passage into the first professional year of the Doctor of Pharmacy program, included a keynote message from Lauretta Okoye, a 1996 graduate of the pharmacy program at Northeastern, and owner of three pharmacies, including Whittier Street Pharmacy in Roxbury, where she has employed co-op students for many years. READ MORE
Malav Trivedi, PhD, Receives RISE Award for Research
Malav Trivedi, a recent PhD program graduate from the laboratory of Professor Richard Deth, was awarded first place in Northeastern University Annual Research, Innovation and Scholarship Expo (RISE) program this spring. Malav also received a $95,000 postdoctoral research fellowship provided by the A2 Corporation, a New Zealand-based supplier of milk and dairy products and continues his work at Northeastern. READ MORE
Welcome New Faculty
Expanding its research, teaching and clinical programs, the school welcomed many new talented members this fall. READ MORE
School Reception at the ASHP Midyear Clinical Meeting
The School of Pharmacy will be hosting its Annual Alumni and Friends Reception at the American Society of Health-System Pharmacists (ASHP) Midyear Clinical Meeting. The event will take place on at 5:30 pm on Monday, December 9, 2013 at the Rosen Centre Hotel in Orlando, Florida.
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The School of Pharmacy is pleased to announce the launch of a new collaboration with Cubist Pharmaceuticals, Inc., to offer its Post-Doctoral PharmD Pharmaceutical Industry Fellowship Program. Cubist Pharmaceuticals is a biopharmaceutical company that focuses on the research, commercialization and creation of pharmaceutical products that address unmet medical needs in the acute care environment. The fellowship provides PharmD graduates with in-depth experiences in a biopharmaceutical industry setting as well as teaching and research opportunities in an academic/clinical setting, working as visiting scholars of the School of Pharmacy. At Northeastern, the program is led by Andrew Skirvin, Clinical Associate Professor and Fellowship Coordinator, and David Zgarrick, Professor and Chair of the Department of Pharmacy Practice. Fellows are also under the leadership of Scott McConnell and Monica Crompton, who serve as Director and Assistant Director of the fellowship at Cubist Pharmaceuticals. As a previous fellow at Cubist and Northeastern alumni, Dr. Crompton is looking forward to working closely with her alma mater stating, “I am very excited for the partnership between Cubist and Northeastern. Through this collaboration our fellows will have the unique opportunity to get an experience in both the pharmaceutical industry and academic setting while engaging with motivated faculty members on a variety of activities. This truly is a well-rounded and invaluable experience that will set our fellows apart.”
While at the Cubist headquarters, located approximately 15 miles from campus in Lexington, MA, fellows spend 2 years as integral members of either the Clinical Research or Medical Affairs department. In Clinical Research, fellows are given the opportunity to experience all phases of human-subjects research, ranging from first-in human Phase 1 studies through Phase 4 post-approval studies, all while functioning as active members of multidisciplinary teams within and outside of Clinical Research. Medical Affairs fellows gain valuable experiences as key members of teams ranging from Medical Information and Health Economics Outcomes Research to Strategy and Operations.
The program is currently comprised of 8 fellows, with 3 fellows in Clinical Research and 5 fellows in Medical Affairs. The joint collaboration between Northeastern and Cubist offers fellows exceptional post-graduate training as Myra Wooley, a second-year Clinical Research fellow, describes, “I am excited to be in the first group of Northeastern Fellows at Cubist. The fellowship is an opportunity for graduates to engage in research and teaching at Northeastern while exploring the many roles a PharmD can play in the Pharmaceutical Biotech Industry. The academic and industrial settings not only provide fellows with projects and resources to develop transferable skills but also provide mentorship and experiences to help guide their future career decisions.”
With Midyear around the corner, fellows and program leads are excited to recruit for next year’s fellowship class and continue to foster the program. For more information on the Cubist/NEU fellowship, please click here. (Back to top)
Area hospital pharmacists, residents, fellows, faculty, students, and guests were inspired by the words of Ray R. Maddox, BS, PharmD, FASHP, Director of Clinical Pharmacy, Research and Pulmonary Medicine at St. Joseph’s/Candler Health System in Savannah, Georgia. Dr. Maddox was the 2013 recipient of the John W. Webb Visiting Professor Lecture in Hospital Pharmacy and spoke on the topic of The Essence of Leadership. The Northeastern event was held thanks in part to the organizational sponsorship of ASHP, Massachusetts Society of Health-Systems Pharmacist, Grifols, USA, LLC, and the Northeastern School of Pharmacy.
The Webb Lecture Program, now in its twenty-ninth year, has become among the most respected events in pharmacy. The theme of the lecture series is Excellence in Management. Each year, a hospital pharmacy practitioner is selected for the award by a committee appointed by the American Society of Health-System Pharmacists. Appointment to the John W. Webb Visiting Professorship recognizes commitment to hospital pharmacy management, experience as a practitioner and educator, and dedication to excellence in pharmacy management. Past lecturers represent the best and brightest in the field, and have been assembled from some of the most prestigious medical centers in the USA. Each lecture is published annually in the American Journal of Health-System Pharmacy, following two lecture events, one in Chicago and one in Boston.
The Northeastern Webb lecture was attended this year by more than 125 faculty, practitioners, students, and residents. Prior to the lecture, 70 residents from area hospitals participated in round table discussions facilitated by past Webb lecturers.
The John W. Webb Visiting Professorship in Hospital Pharmacy is held annually in October. For more information, please contact the School of Pharmacy Dean’s office at firstname.lastname@example.org. (Back to top)
Students, along with their families and guests, gathered to attend the Class of 2017 White Coat Ceremony on November 3, 2013. The ceremony, held in Blackman Auditorium, signifies students’ passage into the first professional year of the Doctor of Pharmacy (PharmD) program. Nearly 600 guests attended the coating ceremony and reception that followed.
This year’s keynote speaker was Lauretta Okoye, a 1996 graduate of the pharmacy program at Northeastern, and owner of three pharmacies, including Whittier Street Pharmacy in Roxbury, where she has employed co-op students for many years. In addition to being a preceptor, she has participated in the Bouvé College Health Science Entrepreneurs programs, served as a speaker in last year’s induction ceremony of our student chapter of the National Community Pharmacists Association, and presented this summer in Prof. Zgarrick’s Pharmacy Management course. Mrs. Okoye was joined by her husband, Jonas, also a Northeastern alumnus, and her children, including Chioma Okoye who is a member of the Class of 2017 (pictured above).
Families and friends attended from international locations and from all over the country and enjoyed mingling with students, faculty and administration at a reception following the ceremony. The day’s events were co-sponsored by Shaws/Osco, CVS/Pharmacy, Walgreens, and Stop & Shop/Ahold, and the School of Pharmacy Dean’s fund. (Back to top)
Malav Trivedi a recent PhD program graduate from the laboratory of Professor Richard Deth. was awarded first place in Northeastern University's annual Research, Innovation and Scholarship Expo (RISE) this spring. Malav’s thesis project is titled “A novel role of Redox/methylation signaling as an epigenetic-based mechanism for opioid drug action”
Malav’s work focuses on investigating the epigenetic changes and consequent gene expression changes under the influence of redox status of neurons, especially in relation to neurodevelopmental and Neurological disorder. One part of Malav’s work focuses on studying the effects of opioid and food derived opioid peptides with implications in Autism spectrum disorders (ASD) and Drug Addiction. ASD are a heterogeneous group of neurodevelopmental disorders with genetic and environmental etiologies. Many parents report cognitive and behavioral improvement upon removal of casein and gluten (GF/CF) from their child's diet, however, the evidence is anecdotal. Peptides like β-casomorphin-7 (βCM7) and α-gliadin-7 (αG7) are formed after ingestion of milk and wheat/rye, respectively, and these can activate opiate receptors at low nanomolar concentrations. Blood and urine samples from autistic and schizophrenic patients contain higher amounts of these peptides, suggesting a possible contribution to these disorders. A SNP in casein results in higher amounts of βCM7 being produced from the milk of certain cows (A1 vs. A2), and several studies have shown a correlation between A1 milk consumption and inflammatory disorders.
Systemic oxidative stress and brain neuro-inflammation have also been described in autistic subjects, in association with significantly lower plasma levels of the antioxidant glutathione (GSH). Cysteine availability is rate-limiting for GSH synthesis and the excitatory amino acid transporter-3 (EAAT3) provides a major source of cysteine uptake in both neurons and intestinal epithelial cells. The levels of glutathione regulate the levels of S-adenosyl methionine (SAM) via the activity of methionine synthase enzyme. SAM is a methyl donor for more than 200 methylation reactions including DNA and Histone methylation.
Malav’s work shows that αG7, as well as human and bovine forms of βCM-7 potently inhibit cysteine uptake in cultured human SH-SY5Y neuroblastoma and Caco-2 intestinal epithelial cells with significant changes in intracellular thiol levels, including a decrease in the level of GSH. Their acute inhibition of cysteine uptake was similar to the effect of morphine, but less extensive, and was completely blocked by the opiate antagonist naltrexone, confirming opiate receptor involvement. The bovine form of βCM-7 was more potent as compared to the human form in inhibiting cysteine uptake and altering thiol metabolite levels, which promotes breast-feeding for Autistic kids.
Recently, Malav has also characterized the effects of these opioid peptides on DNA methylation at 270,000 sites on the DNA in neuronal cell culture, as well as subsequent gene expression changes using genome-wide microarray technology. Preliminary results support the hypothesis, and suggest that opioids and food-derived opioid peptides induce oxidative stress and epigenetic changes which affect neuro-plasticity, and hence, a GF/CF dietary intervention would restore the homeostasis and normal brain functioning. The current study provides a novel mechanistic explanation for the benefit of GF/CF dietary intervention for the treatment of autism and other inflammatory disorders.
Malav’s work is funded by Autism Research Institute, A2 Milk Corp, and National Institute of Drug Abuse. (Back to top)
Dr. Jennifer Bhuyian
Dr. Bhuyian joins the Department of Pharmacy Practice as an Assistant Clinical Professor. She received her Doctor of Pharmacy from St. John’s University in Queens, NY. She subsequently completed a PGY1 Pharmacy Practice Residency at The Brooklyn Hospital Center in Brooklyn, NY in and a PGY2 Advanced Pharmacy Practice Residency with an emphasis in underserved care and global health at the University of Pittsburgh Medical Center, Pittsburgh, PA. As a resident, she had the opportunity to practice with and teach students, patients and other health care professionals in a variety of underserved settings in the U.S. and abroad. Dr. Bhuiyan received the St. Luke/St. Martin De Porres Award for Service from St. John’s University in 2011 and Resident of Excellence in Education Award from the University of Pittsburgh. Dr. Bhuiyan practices at Lynn Community Health Center in Lynn, MA, where she serves a multicultural, underserved patient population. Her research and teaching interests are in the areas of global health, public health, primary care, and underserved care.
Dr. Danielle Gingras
Dr. Gingras joins the Department of Pharmacy Practice as an Assistant Clinical Professor. She received her Bachelor’s degree in Pharmacy Studies and her Doctor of Pharmacy (PharmD) from Northeastern University. Dr. Gingras completed a post-graduate training year (PGY-1) with a focus in ambulatory care at the Bay Pines Veterans Administration Healthcare System in Bay Pines, FL. During her residency she also completed a teaching certificate program with Florida A&M University. Dr. Gingras’ clinical focus is in ambulatory care, where she is establishing a clinical practice at Boston Medical Center. Her research interests include the scholarship of teaching and learning (SoTL), teaching with technology, and ambulatory care.
Dr. Tania (Tali) Konry
Dr. Tania Konry joins the Department of Pharmaceutical Sciences as an Assistant Professor. She received her Ph.D. in Biotechnology Engineering from Ben Gurion University in Israel. Before coming to Northeastern, Dr. Konry worked at Harvard Medical School as an Instructor in Surgery and at Massachusetts General Hospital as an Assistant in Bioengineering. Her lab’s research focuses on the application of bioengineering principles to both analysis and manipulation of biological systems. In particular, her research program involves two research thrusts to further advance the understanding of mechanisms of regulation in diseases.
Dr. Thomas Matta
Dr. Matta joins the Department of Pharmacy Practice as an Assistant Clinical Professor. He received his Doctor of Pharmacy degree from Xavier University of Louisiana College of Pharmacy. He has completed a PGY-1 residency in community pharmacy at The University of Iowa College of Pharmacy, and a PGY-2 residency in ambulatory care at The University of Oklahoma College of Pharmacy, where he served as the chief resident. Dr. Matta joins our faculty at Harbor Health Associates, Inc., working with community health centers to provide ambulatory care services. Dr. Matta’s research interests include the benefit of pharmacists in pediatric and adult ambulatory care settings.
Dr. Jeanine Mount
Dr. Mount joins the Bouve College of Health Sciences as Associate Dean of Undergraduate Education and Professor of Practice in the Department of Pharmacy Practice. Dr. Mount comes to Northeastern from the University of Wisconsin-Madison School of Pharmacy where she was Associate Dean for Strategic Initiatives and Co-director of the Pharmaceutical History and Policy Center. Dr. Mount's current research interests focus on two general areas: the effects of organizational and professional characteristics on the process of health service delivery and the social organization of pharmacy and the pharmacy profession in the United States.
Dr. Steven Pizer
Dr. Pizer joins the Department of Pharmacy Practice as an Associate Professor. He received his AB in Social Studies from Harvard College and a PhD in Economics from Boston College. He serves as Director of the Health Care Financing and Economics research group at the US Department of Veterans Affairs. Prior to coming to Northeastern he was an Associate Professor in the Boston University Schools of Medicine and Public Health. His most recent research is focused on observational studies of comparative effectiveness using electronic medical records.
Dr. Jeffrey Agar
Dr. Jeffrey Agar joins the Department of Pharmaceutical Sciences as an Associate Professor. He received his Ph.D. from the University of Georgia in Inorganic Chemistry. Dr. Agar previously worked as an Assistant Professor at Brandeis University and completed his postdoctoral training at McGill University. The goal of his research laboratory is to understand the mechanisms of ALS (aka Lou Gehrig's Disease) and develop potential drugs. His laboratory has two related research interests: (1) that of an analytical mass spectrometry technology development laboratory, and (2) that of a neuroscience laboratory that researches ALS.
Dr. Karrie Juengel
Karrie E. Juengel, PharmD, a graduate from Ferris State University (Michigan), is completing her PGY-1 pharmacy practice residency at Northeastern University – School of Pharmacy in collaboration with Harbor Health Services, Inc – Elder Service Program. She wanted a residency program that offered her the opportunity to provide direct patient care to patients both in a community health center (CHC) and program of all-inclusive care for the elderly (PACE). Additionally, Dr. Juengel is afforded several opportunities to teach / educate through her appointment as adjunct clinical instructor at the University.
Dr. Clara Ofodile
Clara C. Ofodile, PharmD, a graduate from the University of New England (Maine), is completing her PGY-1 pharmacy practice residency at Northeastern University – School of Pharmacy in collaboration with The Dimock Center. She chose this residency because she is passionate about ambulatory care and wanted the opportunity to provide direct patient-care services to a diverse patient population. Dr. Ofodile serves in an active role on an interdisciplinary team and is afforded the opportunity to develop teaching and learning skills, as well as explore opportunities in academia.
Dr. Tayla Thompson
Tayla N. Thompson, PharmD, a graduate from the University of Connecticut, is completing her PGY-1 pharmacy practice residency at Northeastern University – School of Pharmacy in collaboration with Harbor Health Services, Inc – Community Health Centers (Neponset Health Center, Geiger-Gibson Community Health Center and Harbor Community Health Center – Hyannis). She chose this residency because it combines two of her passions: ambulatory care and academia. Dr. Thompson is able to devote her time providing primary care to underserved patients with a spectrum of chronic disease states and at the same time, educates pharmacy students both at the clinic site and in the classroom.
Dr. Charlotte Yum
Charlotte Yum, PharmD, a graduate from St. John's University (New York), is completing her PGY-1 community pharmacy residency at Northeastern University- School of Pharmacy in collaboration with Walgreens Health System Pharmacy located inside the Joslin Diabetes Center. She worked as a pharmacist at Walgreens for a year prior and chose to pursue a residency to expand her skills and explore the different roles of a community pharmacist . Alongside from teaching opportunities at Northeastern University and precepting students, she plays an active role managing a discharge medication Bedside Delivery Program at her site with Beth Israel Deaconess Medical Center, working with the transplant team and collaborating with diabetes educators at the Joslin Center. She has an interest in transitions of care research and working to expand the clinical services provided by community pharmacists.
School of Pharmacy
140 The Fenway
Welcome to Cubist Fellows!
L-R: Melissa Palchak, Jasmine Sahni, Chad Glasser, Lucy Gong, Brock Bumpass, Nainee Desai, Myra Wooley and Anu Randhawa are the new Cubist Fellows at Northeastern.
White Coat Ceremony
Lauretta Okoye, keynote speaker and a 1996 graduate of the pharmacy program at Northeastern is pictured here with daugher Chioma, class of 2017.
Bill Gouveia and Jack Reynolds with Ray Maddox, the 2013 Webb Lecturer, and his wife Kay.
White Coat Ceremony
Class of 2017 Officers Kevin DeLeonardo, Aditi Desai and Alexandra Kowicz celebrate at the White Coat Ceremony
Webb Lecture Attendees