Julie G. Hensler, PhD

Associate Professor, US Army Graduate Program in Anesthesia Nursing
  • School of Nursing

Office: US Army - University of Texas Health Science Center - San Antonio Texas
Email: hensler@uthscsa.edu

Education and Training: 
PostDoc  University of Pennsylvania
PhD         Pharmacology, Northwestern University Medical School, Chicago
BA           Biology & Psychology, State University of New York, Binghamton

Research Interests: 
Understanding the neural basis of stress-precipitated psychiatric disorders such as major depression.

Funding: 
Current
Mechanisms of co-morbidity between epilepsy and depression (Mazarati) Agency: National Institute of Neurological Disorders and Stroke
Type: R01 NS 065783, Period: 05/01/14-04/30/18
Role: Co-investigator (Effort: 5%)
Completed
5-HT Transporter Function: Interaction of antidepressants and hormones (Frazer) Agency: National Institute of Mental Health
Type: R01 MH 090386, Period: 06/01/10-4/30/15.
Role: Co-investigator (Effort: 5%)
Neuroinflammation and BDNF dysfunction: increased risk of depression associated with obesity (Hensler) Agency:  University of Texas Health Science Center ~ San Antonio
Type: Center for Biomedical Neuroscience Pilot Project. Period: 2/01/14 – 2/31/15.
Novel therapeutic targets to treat social deficits in autism and related disorders (Gould) Agency: Department of Defense
Type: Idea Development, Period: 09/30/12-09/29/15 Role: Co-investigator (Effort: 5%)
Vagal nerve stimulation and antidepressants: cFOS, ∆FOSB and Activation of TrkB (Frazer) Agency:  National Institute of Mental Health
Type: R01 MH 082933, Period: 8/04/08-5/31/13.
Role: Co-investigator
Impact of Moderate Maternal Nutrient Restriction on Key Serotonergic Parameters in the Fetal Brain (Hensler) Agency: Morrison Trust
Period: 10/01/11- 9/30/1012
Increased vulnerability of BDNF deficient mice to mild stress  (Hensler) Agency:  National Institute of Mental Health
Type: R21 MH 083300-01, Period:  5/1/09-4/30/12 (no cost extension).
Serotonin Club Meeting 2010 (Hensler) Agency: National Institute of Mental Health
Type: R13 MH 091948, Period: 07/01/10-06/30/11.
Neurobiological basis of Depression as a Comorbidity of Epilepsy (Mazarati) Agency: National Institute of Mental Health
Type: R21 MH 079933-01, Period: 06/01/09-03/31/11.
Role: Co-investigator
Obesity and insensitivity to antidepressant drugs (Hensler)  Agency: San Antonio Area Foundation, Period: 06/01/09-11/30/10.
Serotonin Receptor Subtypes: Regulation and Interaction  (Hensler) Agency:  National Institute of Mental Health
Type:  R01 MH 52369-09, Period:  6/1/04-5/31/10.
5-HT transporter and 1A receptor function in BDNF (+/-) mice (Hensler) Agency:  National Institute of Mental Health
Type: R21 MH071488-01, Period: 4/01/06-3/31/09.
Behavioral and neurochemical effects of antidepressants in BDNF deficient mice (Hensler) Agency:  NARSAD
Type: Independent Investigador Award, Period: 9/15/04-9/14/06.
Serotonin Receptor Subtypes: Regulation and Interaction (Hensler) Agency:  National Institute of Mental Health
Type:  R01 MH 52369-06, Period:  4/1/01- 5/31/04.
BDNF Deficient Mice: A Model for Substance Abuse (Hensler) Agency: San Antonio Area Foundation, Period: 6/01/03 – 5/31/04.
Early Onset Alcoholism: From Molecules to Mice to Men (Lamb)
Agency:  University of Texas Health Science Center, Period: 8/01/02 – 7/31/03. Role: Co-investigator.
Serotonergic markers of drug and alcohol abuse (Hensler) Agency: San Antonio Area Foundation, Period: 7/01/00 – 6/30/01.
Characterization of the serotonin1A receptor and serotonin transporter in strains of rat as potential models for alcohol and drug abuse (Hensler)
Agency: South Texas Health Research Center, Period: 10/01/99 – 6/30/01.
Mechanisms of antagonist-induced desensitization of the serotonin-2A receptor  (Hensler) Agency: Pharmaceutical Research and Manufacturers of America Foundation
Type:  Fellowship  for  Advanced  Pre-doctoral  Training  in  Pharmacology  and  Toxicology,  for  N.R.  Hanley, Period: 1/01/99 – 12/31/00.
Antagonist-Induced Desensitization of Serotonin-2A Receptors (Hensler) Agency:  University of Texas Health Science Center
Type: Institutional Research Grant, Period: 6/01/99 – 5/31/00.
Utilization of Antisense Oligodeoxynucleotides to Explore the Influence of Serotonin-2A receptors on Serotonin-1A receptor sensitivity (Hensler)
Agency: NARSAD
Type: Young Investigator Award, Period: 7/01/95 – 8/31/96.
The Pharmacology of Ondansetron, Subproject II:  Effects of Ondansetron On 5HT1A  and 5-HT2A  Receptor Number and Function (Hensler)
Agency: Glaxo-Wellcome, Inc.    Period: 1/25/96.
Ipsapirone and the Regulation of 5-HT1A  and 5-HTReceptors (Hensler) Agency: Miles Inc, Period: 1/01/94 – 12/31/95.
Serotonin Receptor Subtypes:  Regulation and Interaction (Hensler) Agency: National Institute of Mental Health
Type: F.I.R.S.T. Award, R29 MH52369, Period: 9/01/93 – 5/30/99.

Publications:
Dugan A.M., Parrott J.M., Redus L., Hensler J.G., O’Connor J.C.: Low-level stress induces production of neuroprotective factors in wild-type but not BDNF+/- mice: interleukin-10 and kynurenic acid. Int J Neuropsychopharmacol. 2015 Aug 1. pii: pyv089. doi: 10.1093/ijnp/pyv089. [Epub ahead of print]
Altieri S.C., Yang H., O’Brien H.J., Redwine H.M., Senturk D., Hensler G., and Andrews A.M.: Perinatal vs. genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology. 2014 Dec 19. doi: 10.1038/npp.2014.331. [Epub ahead of print]
Halade G.V., Ma Y., Ramirez T.A., Zhang J., Dai Q., Hensler J.G., Lopez E.F., Ghasemi O., Jin Y.-F. and Lindsey M.L.: Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice. American Journal of Physiology – Heart and Circulatory Physiology 305(12):H1830-42,   2013.
Gould G.G., Burke T.F., Osorio M., Onaivi E., Gu T.-T., DeSilva M., and Hensler, J.G.: Enhanced novelty- induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid  CB1  receptors  in adolescent BTBR mice. Psychoneuroendocrinology   39:158-169, 2014.
Fuss J., Vogt M., Weber K.-J., Burke T., Gass P. and Hensler J.G.: Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long term voluntary wheel running. Synapse. 67:648- 655, 2013.
Burke T.F., Advani T., Adachi M., Monteggia L.M., and Hensler G.: Sensitivity of hippocampal serotonin1A receptors to stress in mice deficient in brain-derived  neurotrophic  factor.  Int.  J. Neuropsychopharmacology  16:631-645,  2013.
Gould G.G., Seillier A., Weiss G., Giuffrida A., Burke T.F., Hensler J.G., Rock C., Tristan A., McMahon L.R., Salazar A., O’Connor J.C., Satsangi N., Satsangi R.K., Gua T.-T., Treat K., Smolik C. and Schultz S.T.:  Acetaminophen  differentially  enhances  social  behavior  and  cortical  cannabinoid  levels  in  inbred mice. Prog Neuropsychopharmacol Biol Psychiatry 38:260-269, 2012.
Pineda E.A., Hensler J.G., Sankar R., Shin D., Burke T.F., and Mazarati A.M.: Interleukin-1beta causes fluoxetine resistance in an animal model of epilepsy-associated  depression. Neurotherapeutics. 9:477- 485, 2012.
Hensler J.G., Advani T., Burke T.F., Cheng K., Rice  K.C.,  and  Koek  W.:  GABAB  receptor-positive modulators: brain region-dependent effects. J. Pharmacol. Exp Ther. 340:19-26, 2012.
Pineda E.A., Hensler J.G., Sankar R., Shin D., Burke T.F., and Mazarati A.M.: Plasticity of presynaptic and postsynaptic serotonin1A receptors in an animal model of epilepsy – associated depression. Neuropsychopharmacology  36:1305-1316,  2011.
Gould G.G., Hensler J.G., Burke T.F., Benno R.H., Onaivi E.S. and Daws, L.C.: Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and  effects  of  their  targeting  on BTBRT+tf/J mouse social behavior. J. Neurochemistry 116:291-303, 2011.
Hensler J.G., Vogt M.A., and Gass P.: Regulation of cortical and hippocampal 5-HT1A receptor function by corticosterone in GR+/- mice. Psychoneuroendocrinology, 35:469-474, 2010.
Seillier A., Advani T., Cassano T., Hensler J.G., and Giuffrida A.: Inhibition of fatty acid amide hydrolase and CB1 receptor antagonism differentially affect behavioral responses in normal and PCP-treated rats. Int. J. Neuropsychopharmacology  13:373-386,  2010.
Advani T., Koek W., and Hensler J.G.: Gender differences in the enhanced vulnerability of BDNF+/- mice to mild stress. Int. J. Neuropsychopharmacology 12:583-585, 2009.
Lapiz-Bluhm M.D.S., Soto-Pina A.E., Hensler J.G., and Morilak D.A.: Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats. Psychopharmacology 202:329-41, 2009.
Rossi D.V., Burke T.F., and Hensler, J.G.: Differential regulation of serotonin-1A receptor-stimulated [35S]GTPgammaS binding in the dorsal raphe  nucleus  by  citalopram  and  escitalopram.  Eur.  J. Pharmacol. 583:103-107, 2008.
Rossi D.V., Burke T.F., McCasland M. and Hensler J.G.: Serotonin1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline. J. Neurochemistry 105:1091-1099, 2008.
Daws L.C., Munn J.L., Valdez M.F., Frosto-Burke T. and Hensler J.G.: Serotonin Transporter Function, but not  expression, is dependent on Brain Derived Neurotrophic Factor (BDNF): In Vivo Studies in BDNF- deficient Mice. J Neurochemistry 101:641-651, 2007.
Hensler J.G., Advani T. and Monteggia L.M.: Regulation of 5-HT1A receptor function in inducible BDNF knock-out mice following administration of corticosterone. Biol. Psychiatry 62:521-529, 2007.
Advani T., Hensler, J.G. (corresponding author) and Koek, W.: Effect of early rearing conditions on alcohol drinking and 5-HT1A  receptor function in C57BL/6 mice. Int. J. Neuropsychopharmacol. 10:595-607, 2007.
Uphouse L, Hensler J.G., Sarkar J. and Grossie B.: Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats. Brain Research 1072:79-90, 2006.
Rossi D.V., Valdez M., Gould G.G.,  and  Hensler,  J.G.:  Chronic  administration  of  venlafaxine  fails  to attenuate 5-HT1A receptor function at the  level  of  receptor-G  protein  interaction.  Int  J. Neuropsychopharmacol. 9:393-406, 2006.
Garcia A.S., Barrera G., Burke  T.F.,  Ma  S.,  Hensler  J.G.  and  Morilak,  D.A.:  Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. J Neurochemistry 91:683-693, 2004.
Sullivan N.R., Burke T., Siafaka-Kapadai A., Javors M. and Hensler J.G.: Effect of valproic acid on 5-HT2A receptor signaling in C6 glioma cells. J. Neurochemistry 90:1269-1275, 2004.
Hensler J.G., Hodge C.W. and Overstreet D.H.: Reduced 5-HT3  receptor binding and lower baseline plus maze anxiety in the alcohol-preferring inbred fawn-hooded rat. Pharmacol Biochem Behavior 77:281-289, 2004.
Hensler J.G., Ladenheim E.E. and Lyons W.E: Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice. J. Neurochemistry 85: 1139-1147, 2003.
Valdez M., Burke T.F. and Hensler J.G.: Selective heterologous regulation of 5-HT1A receptor-stimulated [35S]GTPγS binding  in  the  anterior  cingulate  cortex  as  a  result  of  5-HT2   receptor  activation.  Brain Research  957: 174-182, 2002.
Duncan, M.J. and Hensler J.G.: Aging alters in a region-specific manner serotonin transporter sites and 5HT1A  receptor-G protein interactions in hamster brain. Neuropharmacology 43: 36-44, 2002.
Hensler J.G.: Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26: 565-573, 2002.
Hanley N.R.S. and Hensler J.G.: Mechanisms of ligand-induced desensitization of the 5-HT2A receptor. J. Pharmacol. Exp. Ther. 300: 468-477, 2002.
Anji A., Sullivan Hanley N.R., and Hensler J.G.: The role of PKC in the regulation of serotonin2A (5-HT2A) receptor expression. J. Neurochemistry. 77:589-597,  2001.
Haywood J.R., Mifflin S.W., Craig T., Calderon A., Hensler J.G. and Hinojosa-Laborde C. GABA-A function and binding in the PVN in chronic renal wrap hypertension. Hypertension 37:614-618, 2001.
Hensler J.G. and Durgam H.: Regulation of 5-HT1A receptor-stimulated [35S]GTPγS binding as measured by quantitative  autoradiography  following  chronic  agonist  administration.   Br.  J.  Pharmacol.  132:605-611, 2001.
Johnson B.A., Roache J.D., Javors M.A., DiClemente C.C., Cloninger C.R., Prihoda T.J., Bordnick P.S., Ait-Daoud N., and Hensler J.: Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled study. J.A.M.A., 284:963-971, 2000.
Anji A., Kumari M., Sullivan Hanley N.R., Bryan G.L. and Hensler J.G.:   Regulation of 5-HT2A  receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin. Neuropharmacology, 39:1996-2005,  2000.

Honors and Awards: 
Award for Exceptional Scholarly Achievement, Research, and Scholarship (2010). Graduate School of Biomedical Sciences, University of Texas Health Science Center-San Antonio.
Independent Investigator Award (2004). National Alliance for Research on Schizophrenia and Depression.
Merit Award in Recognition of Research Endeavors, Presidential Research Enhancement Fund (2004). University of Texas Health Science Center-San Antonio.
Research Incentive Award, Presidential Research Enhancement Fund(2003). University of Texas Health Science Center-San Antonio.
Individual National Research Service Award – Post-doctoral,  F32 MH09834 (1989 to 1990) “Compensatory Regulation of Serotonin 5-HT1A  Receptors.”
Individual National Research Service Award – Pre-doctoral,  F31 MH09215 (1984 – 1986) “Autoreceptor Sensitivity After Antidepressant Treatment.”
Northwestern Medical Practice Scholar (1982) Northwestern University Medical School.

Professional and Community Service:
Member, Executive Committee, Division for Pharmacology Education
American Society for Pharmacology and Experimental Therapeutics – 2013 to 2016
President (elected office) International Society for Serotonin Research ~ formerly The Serotonin Club – 2010 to 2012
Director of Women in Science (elected office), San Antonio Chapter Healthcare Businesswomen’s Association. A global organization of professional women in healthcare – 2009 to 2012
Member, Serotonin Receptor Nomenclature Committee International Union of Basic and Clinical Pharmacology (IUPHAR) – 2009 to present
Vice President (North America) Serotonin Club (An international society of biomedical scientists) – 2009 to 2010
Member, Program Committee, San Antonio Chapter Healthcare Businesswomen’s Association (A global organization of professional women in healthcare) – 2007 to 2012
Councilor, (North America) Serotonin Club (An international society of biomedical scientists) 2004 to 2008
Member, Committee on Minorities American Society for Pharmacology and Experimental Therapeutics – 2004 to 2007
Graduate School Committee Service
Representative of the Pharmacology Track, IMGP Task Force, Integrated Multidisciplinary Graduate Program, UT Health Science Center-San Antonio – 2012
Member, GSBS Awards Committee, Graduate School of Biomedical Sciences, UT Health Science Center-San Antonio – 2012 to 2014
Member, IMGP Review Committee, Integrated Multidisciplinary Graduate Program, UT Health Science Center-San Antonio – 2011 to 2012
Student Advisor, Pharmacology Track, Integrated Multidisciplinary Graduate Program, UT Health Science Center-San Antonio – 2008 to present
Member, Curriculum Committee, Pharmacology Track, Integrated Multidisciplinary Graduate Program, UT Health Science Center-San Antonio – 2006 to 2010
Member, Executive Research Committee, Grant Review, Graduate School of Biomedical Sciences, UT Health Science Center-San Antonio  – 2004 to 2008
Departmental  Representative, Summer  Undergraduate  Research  Fellowship  Program,  Graduate School of Biomedical Sciences, UT Health Science Center-San Antonio –  1994 to 2002
Member, Awards Committee, Graduate School of Biomedical Sciences, UT Health Science Center-San Antonio – 1994 to 1997
Community Outreach
Faculty Mentor, McNair Scholars Program, St. Mary’s University, San Antonio – 2012 to 2014
Member, Steering Committee, The Health Cell – 2012
Member, Texas Chapter, Healthcare Businesswomen’s Association – 2012
Member, Council for Excellence in Women’s Health University of Texas Health Science Center, San Antonio – 2009 to present
Board Member, Director-at-Large, Women in Science San Antonio Chapter, Healthcare Businesswomen’s Association – 2009 to 2012
Panelist, “Women in the Business of Healthcare” program, San Antonio Affiliate,  Healthcare Businesswomen’s Association – 2008
Member, San Antonio Chapter, Healthcare Businesswomen’s Association – 2007-2012
Member, Community Advisory Committee,   “Altered States: Alcohol and other Drugs in America”, Witte Museum, San Antonio, TX – 2002
Member, San Antonio-Austin Life Science Association – 2000 to 2003
Member, Technology Advocates of San Antonio – 2000 to 2002
Speaker, Urban Ministries Workshop on Mental Health, Menger Hotel, San Antonio, TX – 1998
Panel Judge, Brain Bowl, University of Texas Health Science Center- San Antonio – 1998 to present
Lecturer, Licensed Chemical Dependency Counselor Training Course, Ella Austin Community Center, San Antonio, TX  – 1995