Clinton E. Canal

Research Assistant Professor
  • Center for Drug Discovery
  • Research Faculty
  • School of Pharmacy

Résumé/CV:
Office: 211C Mugar Hall
Email: c.canal@northeastern.edu

Education/degrees: 
Ph.D. in Neuroscience, University of Illinois, Urbana-Champaign
B.S. in Psychology, University of Florida
Minor in Philosophy, University of Florida

Research:
function of serotonin systems, e.g. serotonin 2C and serotonin 7 receptors, drug discovery targeting serotonin systems to treat psychiatric disorders, e.g. schizophrenia and depression, neurobiology of psychiatric disorders, pharmacology (molecular, behavioral, and psycho-)

Courses:
PSC G222: The Chemistry and Biology of Drugs of Abuse (Guest lecturer)

Recent Publications:

Canal, C.E., Morgan, D. (2012).  Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its current utility as a model.  Drug Testing and Analysis. DOI: 10.1002/dta.1333

Cordova-Sintjago, T.C., Sakhuja, R., Kondabolu, K., Canal, C.E., Booth, R.G. (2012) Molecular determinants for ligand binding at serotonin 5-HT2A and 5-HT2C GPCRs: Affinity results analyzed by molecular modeling and ligand docking studies. International Journal of Quantum Chemistry. DOI: 10.1002/qua.24237

Canal, C.E., Cordova-Sintjago, T.C., Villa, N.Y., Fang, L., Booth, R.G. (2011).  Drug discovery targeting human 5-HT2C receptors: Residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation. European Journal of Pharmacology. DOI: http://dx.doi.org/10.1016/j.ejphar.2011.10.006

Cordova-Sintjago, T.C., Villa, N.Y., Canal, C.E., Booth, R.G. (2011).  Human serotonin 5-HT2C G protein-coupled receptor homology model from the β2 adrenergic receptor structure: ligand docking and mutagenesis studies.  International Journal of Quantum Chemistry. DOI: 10.1002/qua.23231