The Cellular/Molecular Biology, Genetics, and Biochemistry Group uses integrated approaches to study questions related to organismal development and repair. A unifying theme among the group is an interest in discovering mechanisms of dynamic developmental change, for example, the expression of key molecules promoting embryogenesis and regeneration, or interactions between circadian and developmental timing systems. We use cutting-edge genomic and proteomic analyses to pinpoint evolutionary changes in developmentally important genes, and sophisticated technology in gene imaging and quantification. Understanding the basic mechanisms that alter gene expression during development will lead to better understanding of the interaction of the genome with the environment and ultimately to the translation of basic research to new therapeutic approaches in the clinic. The group is supported by grants from the National Institutes of Health, the National Science Foundation, the Mathers Foundation, and Aid for Cancer Research. Associated with this group is the New England Inflammation and Tissue Protection Institute from which novel anti-cancer protocols, currently in clinical trials, have emerged from pioneering work on anti-hypoxia-adenosinergic immunotherapies of cancer. Publications from the Cellular/Molecular Biology, Genetics, and Biochemistry Group have appeared in Nature, Developmental Biology, and Neuroscience, among other distinguished journals, and have been featured in press releases, editorials, and videos.