Shashi MurthyFaculty Fellow, Barnett Institute
Associate Professor and Acting Chair of Chemical Engineering
Associate Professor of Mechanical & Industrial Engineering
Scientific investigator, Massachusetts General Hospital & Shriners Burns Hospital
342 Snell Engineering Center
360 Huntington Avenue
Boston, MA 02115
1999 B.S., Chemical Engineering, Johns Hopkins University
2003 Ph.D., Materials Science & Engineering, Massachusetts Institute of Technology
2003-2005 Postdoctoral Fellowship, Harvard Medical School & Massachusetts General Hospital
The primary focus of my research is the design of microfluidic devices for applications in clinical diagnostics and regenerative medicine. These devices are fabricated using technology originally designed for the semiconductor industry and are capable of handling and manipulating small volumes of fluids (down to tens of microliters) and small numbers of cells. Our expertise is in functionalizing microfluidic channels with a broad range of biomolecules and achieving high-resolution cell separation with these simple and easy-to-use devices.
2009 Søren Buus Outstanding Research Award, College of Engineering, Northeastern University
2008 National Science Foundation Faculty Early Career Development (CAREER) Award
1999 Presidential Fellowship, Massachusetts Institute of Technology
1999 Loy Wilkinson Award for academic excellence, leadership, and service in Chemical Engineering, Johns Hopkins University
Selected Recent Publications (click here for full list)
G. Hansmann, B.D. Plouffe, A. Hatch, A. von Gise, H. Sallmon, R.T. Zamanian, and S.K. Murthy, "Design, Validation, and Clinical Application of an Endothelial Progenitor Cell Microfluidic Capture Chip in Patients with Cardiovascular Disease," 2011 Journal of Molecular Medicine (published online).
B.D. Plouffe, L.H. Lewis, and S.K. Murthy. "Computational Design Optimization for Microfluidic Magnetophoresis," Biomicrofluidics 2011, 5, 013413.
D.A.L. Vickers, M. Hincapie, W.S. Hancock, and S.K. Murthy. "Lectin-Mediated Microfluidic Capture and Release of Leukemic Lymphocytes from Whole Blood," Biomedical Microdevices 2011, 13, 565-571.
J.V. Green, D. Sun, A. Hafezi-Moghadam, K. Lashkari, and S.K. Murthy. "Microfluidic Pillar Array Sandwich Immunofluorescence Assay for Ocular Diagnostics," Biomedical Microdevices 2011, 13, 573-583.
A. Hatch, G. Hansmann, and S.K. Murthy. "Engineered Alginate Hydrogels for Effective Microfluidic Capture and Release of Endothelial Progenitor Cells from Whole Blood," Langmuir 2011, 27, 4257-4264.
R.J. Camp, M. Lilies, J. Beale, N. Saedi, B. Flynn, E. Moore, S.K. Murthy, and J.W. Ruberti. "Molecular Mechanochemistry: Strain-Dependent Enzymatic Cleavage of Human Type I Collagen Monomer," Journal of the American Chemical Society 2011, 133, 4073-4078.
D.A.L. Vickers and S.K. Murthy. "Receptor Expression Changes as a Basis for Endothelial Cell Identification Using Microfluidic Channels," Lab on a Chip 2010, 10, 2380-2386
A.K.H. Achyuta, K.D. Stephens, H.G. Pryce Lewis, and S.K. Murthy. "Mitigation of Reactive Human Cell Adhesion on Poly(dimethylsiloxane) by Immobilized Trypsin," Langmuir 2010, 26, 4160–4167.
J.V. Green, M. Radisic, and S.K. Murthy. "Deterministic Lateral Displacement as a Means to Enrich Large Cells for Tissue Engineering," Analytical Chemistry 2009, 81, 9178-9182.
B.D. Plouffe, T. Kniazeva, J.E. Mayer, S.K. Murthy, and V.L. Sales. "Development of Microfluidics as Endothelial Progenitor Cell Capture Technology for Cardiovascular Tissue Engineering and Diagnostic Medicine," FASEB Journal 2009, 23, 3309-3314.
J.V. Green and S.K. Murthy. "Microfluidic Enrichment of a Target Cell Type from a Heterogenous Suspension by Adhesion-Based Negative Selection," Lab on a Chip 2009, 9, 2245-2248.
B.D. Plouffe, M.A. Brown, R.K. Iyer, M. Radisic, and S.K. Murthy. "Controlled Capture and Release of Cardiac Fibroblasts using Peptide-Functionalized Alginate Gels in Microfluidic Channels," Lab on a Chip 2009, 9, 1507-1510
J.V. Green, T. Kniazeva, M. Abedi, D. Sokhey, M.E. Taslim, and S.K. Murthy. "Effect of Channel Geometry on Cell Adhesion in Microfluidic Devices," Lab on a Chip 2009, 9, 677-685.