Roger Giese
Senior
Faculty Fellow
Professor of Chemistry and Biomedical Science
Director
of the Environmental Cancer Research Program
Editor, Journal of
Chromatography
The
Barnett Institute, 341 Mugar
Northeastern University
360 Huntington Avenue
Boston MA 02115
email r.giese@neu.edu
voice: 617-373-3227
fax: 617-373-8720
Dr.
Giese's research is in the detection and identification of trace analytes such
as genotoxic chemicals, DNA adducts, environmental contaminants, steroids, and
bio-active peptides by mass spectrometry. The work combines analytical
chemistry, organic chemistry, and biochemistry to advance the reagents and
techniques available for sample preparation. Novel tags are developed for
derivatization to increase analyte response and selectivity.
Environmental
Cancer Research Program Site>>
Prof. Giese's Research Group Site>>
Selected Publications
- Shimelis, O., Giese, R. W. (2006) Nuclease P1 digestion/high-performance liquid chromatography, a practical method for DNA quantitation, J. Chromatogr. A., 1117, 132-136.
- Murugaiah, V., Naim, A., Peng, S., Cui, G., Giese, R. W. (2006) 4-(4'-Methyltetrafluorophenyl) -2,3,5,6-tetrafluorobenzyl bromide: A new electrophoric derivatizing reagent, J. Chromatogr. A, 1134, 338-340.
- Shao, G., Kautz, R., Peng, S., Cui, G., Giese, R. W. (2007) Calibration by NMR for quantitative analysis: p-Toluenesulfonic acid as a reference substance, J. Chromatogr. A, 1138, 305-308.
- Yong. L. C., Schulte, P. A., Kao, C-K., Giese, R. W., Boeniger, M. F., Strauss, G. H.S., Petersen, M. R., Wiencke, J. K. (2007) DNA Adducts in Granulocytes of Hospital Workers Exposed to Ethylene Oxide, Am. J. Ind. Med., 50, 293-302.09.
- Gao, H., Wu, B., Giese, R. Zhu, A. (2007) Xom interacts with and stimulates transcriptional activity of LEF1/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis, Cell Res. 17, 345-356.
- Wang, Y., Cui, G., Zhao, M., Yang, J., Wang, C. Giese, R. W., Peng, S. (2008) Bioassay-directed purification of an acidic phospholipase A2 from Agkistrodon halys pallas venom, Toxicon 51, 1131-1139.
- Wang, P., Li, G., Gao, J., Zhang, X., Giese, R. W. Intensified Neutral Loss Tags and Use thereof in Mass Spectrometry, U.S. Patent 7,556,969 July 7, 2009.
- Wang, P., Giese, R. W. (2009) PCI-like behavior of estradiol in MALDI, Rapid Commun. Mass Spectrom., 23, 2836-2838.160.
- Bono, R., Romanazzi, V., Munnia, A., Piro, S., Allione, A., Ricceri, F., Guarrera, S., Pignata, C., Matullo, G., Wang, P. Giese, R. W., Peluso, M. (2010) Malondialdehyde-Deoxyguanosine Adduct Formation in Workers of Pathology Wards: The Role of Air Formaldehyde Exposure, Chem. Res. Toxicol. 23, 1342-1348.