Dissertation

Wales, T.E. Total chemical synthesis and biophysical characterization of backbone-modified protein analogues. Ph.D. Thesis, Duke University, Durham, NC, 2003, UMI ATT 3129077

Review Articles/Book Chapters

Engen, J.R.; Wales, T.E.; Hochrein, J.M.; Meyn III, M.A.; Ozkam, S.B.; Bahar, I.; Smithgall, T.E.  Structure and Dynamic Regulation of Src-Family Kinases.  Cell. And Mol. Life Sci. 2008, 65, 19, 3058-3073.

Wales, T.E.; Engen, J.R. Hydrogen Exchange Mass Spectrometry for the Analysis of Protein Dynamics.Mass Spectrom. Rev. 2006, 25, 1, 158-170.

Primary research papers

Fang, J; Rand, K.D.; Silva, M.C.; Wales, T.E.; Engen, J.R.; Beuning, P. Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. J. Mol. Biol. 2010, 398, 1, 40-53.

Wales, T.E.; Fadgen, K.E.; Gerhardt, G.C.; Engen, J.R. High-Speed and High-Resolution UPLC Separation at Zero Degrees Celcius. Anal. Chem. 2008, 80, 17, 6818-6820.

Trible, R.; Emert-Sedlak, L.; Wales, T.E.; Ayyavoo, V.; Engen, J.R.; Smithgall, T.E.  Allosteric Loss-of-function Mutations in HIV-1 Nef from a Long-term Non-progressor.  J. Mol. Biol. 2007, 374,1, 121-129.

Weis, D.D.; Hotchko, M.; Wales, T.E.; Ten Eyck, L.F.; Engen, J.R.  Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. J. Am. Soc. Mass. Spec.2006. 17,12, 1700-1703.

Hochrein, J.M.; Wales, T.E.; Lerner, E.C.; Shiavone, A.P.; Smithgall, T.E.; Engen, J.R.  Mapping the solvent exposure of the full length HIV and SIV Nef proteins by mass spectrometry. Biochemistry.2006, 45,25, 7733-9.

Wales, T.E.; Engen, J.R. Partial unfolding of diverse SH3 domains on a wide timescale. J. Mol. Biol.2006, 357, 5, 1592-1604.

Wang, M.; Wales, T.E.; Fitzgerald, M.C. The Thermodynamics of backbone Hydrogen Bonds are Conserved in a Protein Fold. Proc. Natl. Acad. Sci. 2006, 103, 8, 2600-2604.

Wales, T.E.; Richardson, J.S.; Fitzgerald, M.C. Facile Synthesis and Equilibrium Unfolding Properties of CopG. Prot.  Sci. 2004, 13, 1918-1926.

Powell, K.D.; Wang, M.Z.; Silinski, P.; Ma, L.;  Wales, T.E.; Dai, S.Y.; Warner, A.H.; Yang, X. Fitzgerald, M.C. The Accuracy and Precision of a New H/D Exchange-and Mass Spectrometry-Based Technique for Measuring the Thermodynamic Stability of Proteins. Anal. Chim. Acta 2003, 496, 225-232.

Powell, K.D.; Wales, T.E.; Fitzgerald, M.C. Thermodynamic Stability Measurements on Multimeric Proteins Using a New H/D Exchange- and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry-Based Method. Prot. Sci.  2002, 11, 841-851.

Wales, T.E.; Fitzgerald, M.C.F. The Energetic Contribution of Backbone-Backbone Hydrogen Bond to the Thermodynamic Stability of a Hyperstable P22 Arc Repressor Mutant. J. Amer. Chem. Soc. 2001,123, 7709-7710.

National Courses Organized or Taught: 
Protein Structural Analysis by Mass Spectrometry: Hydrogen Exchange and Covalent Labeling, Instructor, 58th American Society for Mass Spectrometry Conference on Mass Spectrometry, 2010.

Protein Structural Analysis by Mass Spectrometry: Hydrogen Exchange and Covalent Labeling,Instructor, 57th American Society for Mass Spectrometry Conference on Mass Spectrometry, 2009.